Browsing Masters Degrees (Medical Microbiology) by Title
Now showing items 1-20 of 21
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Beta-lactam resistance mechanisms in Enterobacter species isolates from Tygerberg Hospital.
(Stellenbosch : Stellenbosch University, 2018-10-31)Background Resistance to carbapenem antibiotics in Gram-negative bacteria is a major public health problem due to limited treatment options. In Enterobacter species, carbapenemase production and reduced membrane permeability, ... -
Development and validation of an in vitro model of dendritic cell identification and activation
(Stellenbosch : Stellenbosch University, 2008-03)ENGLISH ABSTRACT: The aim of this study was to investigate the effect of MBV and Coley’s Toxin on dendritic cells in vitro. The dendritic cell system of antigen presenting cells is the initiator and modulator of the ... -
Development and validation of stabilized whole blood samples expressing T-cell activation markers as quality control reference material
(Stellenbosch : Stellenbosch University, 2008-03)ENGLISH ABSTRACT: Introduction: Flow cytometry has progressively replaced many traditional laboratory tests due to its greater accuracy, sensitivity and rapidity in the routine clinical settings especially clinical trails. ... -
Elucidation of the substrates of mycosin 3, an essential protease of Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects one third of the world’s population and kills 1.7 million people per year. The increasing prevalence of multi- and extensively ... -
Epidemiology and antibiotic susceptibility patterns of mycoplasma sp. and ureaplasma urealyticum
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Overview: Mycoplasmas and ureaplasmas are not routinely diagnosed and are under researched in South Africa. Prevalence, population shifts especially concerning genital flora and implications in infection ... -
The epidemiology of Gram negative bacteraemia at Tygerberg Hospital
(Stellenbosch : Stellenbosch University, 2018-03)Background Escherichia coli and Klebsiella pneumoniae are common causes of Bloodstream Infections (BSI). β-lactam antibiotics, such as cephalosporins and carbapenems, are commonly used to treat these infections. Increasing ... -
Generation of a database of mass spectra patterns of selected Mycobacterium species using MALDI-ToF mass spectrometry
(Stellenbosch : Stellenbosch University, 2008-12)The genus Mycobacterium is a group of acid–fast, aerobic, slow- growing organisms which include more than 90 different species. A member of this genus, Mycobacterium tuberculosis, belonging to the Mycobacterium tuberculosis ... -
Genotypic and epidemiological characterization of Methicillin resistant Staphylococcus aureus (MRSA) and Coagulase Negative Staphylococcal (CoNS) strains isolated at Tygerberg Hospital
(Stellenbosch : Stellenbosch University, 2016-12)Background The global burden of methicillin resistant Staphylococcus aureus (MRSA) can be largely attributed to S. aureus’ ability to acquire the resistance element, SCCmec (Staphylococcal chromosome complex mec). ... -
Genotypic characterization of Staphylococcus aureus isolates causing bacteraemia in patients admitted to Tygerberg Hospital, Western Cape Province, South Africa
(Stellenbosch : University of Stellenbosch, 2010-03)ENGLISH ABSTRACT: S. aureus causes serious infections in the hospital and community settings. The rate of MRSA infections are rapidly increasing worldwide. Currently, at Tygerberg hospital, approximately a third of S. ... -
Improving laboratory techniques to detect M. tuberculosis complex and C. neoformans as the causative agents of chronic meningitis in cerebrospinal fluid of adult patients.
(Stellenbosch : University of Stellenbosch, 2010-03)ENGLISH ABSTRACT: INTRODUCTION Mycobacterium tuberculosis (MTB) and Cryptococcus neoformans are the most common causes of chronic meningitis in South Africa. Conventional microbiology has limited utility in diagnosing ... -
In Vitro antimicrobial synergy testing of Acinetobachter Baumannii
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Acinetobacter baumannii has emerged as one of the most troublesome nosocomial pathogens globally. This organism causes infections that are often extremely difficult to treat because of the widespread ... -
An in vitro investigation of the anti-inflammatory and immunosuppressive effects of the synthetic contraceptives medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A)
(Stellenbosch : University of Stellenbosch, 2005-03)The aim of this study was to investigate the anti-inflammatory and immunosuppressive effects of the synthetic progestins, MPA and NET-A on human cells in vitro. These injectable contraceptives are used extensively ... -
Longitudinal investigation of vaccine specific antibody levels and cellular markers of adaptive immune responses in HIV Exposed Uninfected (HEU) and Unexposed (UE) infants
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Background: In South Africa alone, 30% of women of child-bearing age are infected with HIV. With the increasing focus and success of prevention of mother-to-child transmission (PMTCT) programmes, an ... -
The measurement of apoptosis in HIV-1 infection
(Stellenbosch : University of Stellenbosch, 2006-03)Acquired immunodeficiency syndrome (AIDS) was first reported in 5 homosexual men in Unite States of America in 1981 as a series of opportunistic infections which occasionally occurred in adults. Subsequently, it has been ... -
Molecular detection of Mycobacterium tuberculosis in stool of children with suspected intrathoracic tuberculosis
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH SUMMARY: The bacteriological confirmation of tuberculosis in children is challenging. The current diagnostic gold standard, liquid culture of respiratory specimens, has low sensitivity in paucibacillary paediatric ... -
Molecular diagnostic approach to determine the degree of photoaging of the skin
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Context: Excessive exposure to ultraviolet radiation (UV) results in the risk of acquiring long-term harmful effects such as photoaging, which is characterised by deep wrinkles, roughness, dyspigmentation ... -
Molecular epidemiology of mother-to-child transmission of HIV-1 in children at Tygerberg Hospital
(Stellenbosch : University of Stellenbosch, 2006-12)One of the major routes of transmission of human immunodeficiency virus (HIV) in the developing world is vertical transmission from mother to infant – pre-, intra-, or post-partum. In the Western Cape, HIV-1 subtype C ... -
The molecular epidemiology of pneumocystis jirovecii in Cape Town, South Africa
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT : Pneumocystis jirovecii is an opportunistic fungal pathogen that causes Pneumocystis pneumonia (PCP) in immunocompromized hosts. PCP is associated with substantial morbidity, and mortality rates range ... -
Molecular investigation of the chlorine and antibiotic resistance mechanisms of Escherichia coli isolated from natural water sources in the Western Cape
(Stellenbosch : University of Stellenbosch, 2009-03)Water is used for various purposes and contamination can have severe implications if untreated. One of the most common and cost effective water disinfectants, especially used in developing countries, is chlorine. However, ... -
Sequence-based molecular diagnosis of X-linked agammaglobulinemia in South African individuals
(Stellenbosch : University of Stellenbosch, 2011-03-04)ENGLISH SUMMARY: Background: Primary immunodeficiency disorders (PID) disrupt the proper functioning of the immune system. The prototypic PID is X-linked Agammaglobulinemia (XLA). This disorder is caused by mutations in ...
