Browsing Doctoral Degrees (Molecular Biology and Human Genetics) by Title
Now showing items 1-20 of 91
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2020-12-11 Global transcriptomic investigation of the human macrophage response towards pathogenic/non-pathogenic mycobacteria
(Stellenbosch : Stellenbosch University, 2019-12)Background:Tuberculosis (TB) is a major cause of infection-related mortalityworldwide. In 2017 an estimated 1.3 million people who were HIV-negative died of TB. An estimated 5-10% of infected individual develop active ... -
Analysis and application of evolutionary markers in the epidemiology of Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2008-12)This series of studies includes both methodological analyses, aimed at furthering our understanding of, and improving the tools used in molecular epidemiology, and investigative projects which have used these tools to add ... -
Analysis of copy number variation and disease mechanisms underlying Parkinson’s disease
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT : Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. Although the aetiology of PD is still not fully ... -
Analysis of host determining factors in susceptibility to tuberculosis in the South African coloured population
(Stellenbosch : University of Stellenbosch, 2009-12)ENGLISH ABSTRACT: The infectious disease tuberculosis (TB) still represents a global threat due to its devastating effect on health and the subsequent high mortality rate. Previous studies have indicated that host genetic ... -
Application of spoligotyping in the understanding of the dynamics of Mycobacterium tuberculosis strains in high incidence communities
(University of Stellenbosch. Faculty of Health Sciences. Dept. of Biomedical Sciences., 2007-03)Tuberculosis (TB) is a global health problem and demands rigorous control management efforts. A dramatic increase in the acquisition and spread of drug resistant TB globally has been observed in recent years. A grim picture ... -
A candidate and novel gene search to identify the PFHBII-causative gene
(Stellenbosch : Stellenbosch University, 2004-12)ENGLISH ABSTRACT: Heart failure due to cardiomyopathy or cardiac conduction disease is a major cause of mortality and morbidity in both developed and developing countries. Although defined as separate clinical entities, ... -
A candidate and novel gene search to identify the PFHBII-causative gene
(Stellenbosch : University of Stellenbosch, 2004-12)ENGLISH ABSTRACT: Heart failure due to cardiomyopathy or cardiac conduction disease is a major cause of mortality and morbidity in both developed and developing countries. Although defined as separate clinical entities, ... -
The characterisation of N-Acetyltransferase (NAT) in Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2005-03)ENGLISH ABSTRACT: A gene coding for Arylaminie N-acetyltransferase (NAT) has been found in Mycobacterium tuberculosis, the casual agent of tuberculosis (TB). N-acetyltransferase acetylates and inactivates isoniazid (INH), ... -
Characterization of the innate and adaptive immune systems during active TB disease and during treatment
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Individuals presenting with symptoms of active tuberculosis (TB) disease currently undergo a lengthy diagnostic procedure, followed by an intense six-month treatment regimen. Delays in accurate diagnoses ... -
Characterization of the interaction between acetylcholinesterase and laminin : a template for discovering redundancy
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Apart from its primary function in the synaptic hydrolysis of acetylcholine, acetylcholinesterase (AChE) has been shown through in vitro demonstrations to be able to promote various non-cholinergic ... -
Clinical and laboratory investigation of latex allergy in healthcare workers
(Stellenbosch : Stellenbosch University, 2004-12)ENGLISH ABSTRACT: Healthcare workers (HCWs) wear latex gloves to protect themselves and their patients against the transmission of microbial, viral and bloodborne diseases. These individuals are primarily exposed to ... -
Clinically relevant mutations contributing to drug resistance in Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT: Single nucleotide variants are the underlying driver of drug resistance, strain fitness and adaptation in Mycobacterium tuberculosis and investigating the mechanistic and physiological aspects of these ... -
Detection and Characterization of Mycobacterial Infections Occurring in Phacochoerus africanus (Gmelin, 1788) (Common Warthog)
(Stellenbosch : Stellenbosch University, 2018-12)ENGLISH ABSTRACT: Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex and the cause of bovine tuberculosis (bTB), has an extensive host range that includes livestock and wildlife. While warthogs are ... -
The development of a novel fluorescentmarker phage technology system for the early diagnosis of tuberculosis disease
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative organism of tuberculosis (TB), is a major cause for mortality and morbidity world-wide with a death toll only second to HIV among infectious diseases. Drug ... -
Development of immune-based TB tests suitable for resource limited settings
(Stellenbosch : Stellenbosch University, 2014-12)ENGLISH ABSTRACT: - Background - Tuberculosis (TB) is still one of the leading causes of death in poor socio-economic settings. This situation is encouraged by the lack of simple and rapid tests suitable for rapid ... -
Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: The epidemic levels of drug-resistant tuberculosis (DR-TB) in high-burden countries such as South Africa, which is currently ranked as third highest in the world, is the result of a synergistic relationship ... -
Differential inhibition of adenylylated and deadenylylated Mycobacteriun tuberculosis glutamine synthetase by ATP scaffold-based inhibitors
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: Please refer to full text for abstract -
The effects of a Mycobacterium bovis infection on the metabolic and reproductive systems of African lions (Panthera leo) in the Kruger National Park.
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: SCCHg en SCCmec elemente is, maar verdere filogenetiese ondersoeke moet uitgevoer word, om insig te gee oor die oorsprong en verspreiding van hierdie nuwe element. This thesis serves as an attempt to ... -
Elucidation of the mode of action of a furanone based antituberculosis compound
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: The prevalence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis has been increasing to alarming levels globally. This has been exacerbated by tuberculosis ... -
Elucidation of the structure and function of the Mycosins, a family of essential subtilisin-like serine proteases of Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2014-12)ENGLISH ABSTRACT: Mycobacterium tuberculosis is an ancient pathogen, which has been infecting humans for millennia. It remains globally spread, infecting one third of the world’s population and causing around two million ...
