• Nucleoid gene regulation in mycobacteria 

      Steyn, Nastassja Lise (Stellenbosch : Stellenbosch University, 2017-12)
      ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis disease, remains one of the leading causes of death worldwide. The ongoing tuberculosis epidemic and poor treatment outcomes can be attributed ...
    • Investigating southern African genetic diversity and its role in TB susceptibility 

      Uren, Caitlin (Stellenbosch : Stellenbosch University, 2017-12)
      ENGLISH ABSTRACT: Recent genetic studies have established that the KhoeSan populations of southern Africa are the earliest known indigenous inhabitants of the region and distinct from all other African populations. Owing ...
    • Clinically relevant mutations contributing to drug resistance in Mycobacterium tuberculosis 

      Du Plessis, Juanelle (Stellenbosch : Stellenbosch University, 2017-12)
      ENGLISH ABSTRACT: Single nucleotide variants are the underlying driver of drug resistance, strain fitness and adaptation in Mycobacterium tuberculosis and investigating the mechanistic and physiological aspects of these ...