Browsing Doctoral Degrees (Medical Physiology) by Title
Now showing items 1-20 of 44
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Basic semen parameters assisted by Computer-Aided sperm analysis (CASA) and their correlations with advanced semen parameters in normozoospermic men with different abstinence periods
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Affordable basic semen analysis remains a fundamental procedure to be performed routinely during the diagnosis of male infertility. Advanced semen analyses, provide valuable clinical insights in treatment ... -
Characterisation of high fat, high sugar diet-induced epigenetic changes in skeletal muscle of wistar rats and metabolic effects of an aspalathin-rich rooibos extract
(Stellenbosch : Stellenbosch University, 2021-12)Background Animal models are widely used to elucidate the pathophysiological mechanisms that underlie obesity and to test the efficacy of anti-obesity therapeutics. However, these models have been largely biased towards ... -
Compounds specific to Aspalathus linearis protects the diabetic heart against oxidative stress: a mechanistic study
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT : In diabetics, hyperglycemia, hyperlipidemia and inflammation potentiates the development of cardiovascular diseases (CVDs). These conditions provoke excessive generation of oxidative stress that has been ... -
Contribution of highly active anti-retroviral therapy to the development of non-alcoholic fatty liver disease with concomitant cardiovascular dysfunction in an obese rat model
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: HIV/AIDS mortality is declining due to successful highly active anti-retroviral therapy (HAART). However, obesity, non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) in treated ... -
The dietary ionic effects on sex ratios in animal models
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: X-linked disorders are more expressed in male offspring and prevention of these hereditary diseases is the only recourse to date. Influencing conception towards female offspring can circumvent this problem; ... -
Effect of an obesogenic diet on the epigenetic profile of livers from Wistar rats and treatment with an aspalathin-rich rooibos extract
(Stellenbosch : Stellenbosch University, 2021-12)Background There is a scarcity of knowledge about obesity and metabolic syndrome development and progression in females, who are often under-represented in preclinical research. The aims of this study were thus to ... -
The effect of creatine supplementation on myocardial metabolism and function in sedentary and exercised rats
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Background: There has been a dramatic increase in the use of dietary creatine supplementation among sports men and women, and by clinicians as a therapeutic agent in muscular and neurological diseases. ... -
The effect of Cyclopia maculata extract on β-cell function, protection against oxidative stress and cell survival
(Stellenbosch : Stellenbosch University, 2014-12)ENGLISH ABSTRACT: Insights into the role of oxidative stress and pancreatic β-cell dysfunction in the pathogenesis of type 2 diabetes (T2D) reveals an opportunity for the development of novel therapeutics that directly ... -
Effect of different substrates on functional performance and kinase activation during reperfusion after ischaemia in hearts from obese insulin resistant rats
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Obesity is an important risk factor for the development of insulin resistance, the metabolic syndrome and diabetes and has also been implicated as one of the major risk factors for coronary heart disease. ... -
The effect of green rooibos extract on rat hearts in a pre-diabetic model : an evaluation of the function and mechanisms involved
(Stellenbosch : Stellenbosch University, 2019-03)ENGLISH ABSTRACT: Background— Cardiovascular diseases (CVD) remains the leading cause of death globally, with a rising prevalence of individual risk factors such as obesity and insulin resistance. Furthermore, diabetic ... -
The effects of a green rooibos extract on the reproductive function of obesity-induced insulin resistant or hypertensive male wistar rats
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Diet-induced obesity (DIO) due to a high caloric diet (HCD) predisposes an individual to the development of diabetes and cardiovascular diseases, with high prevalence in young populations. Existing evidence ... -
The effects of early life trauma on the neurochemistry and behaviour of the adult rat
(Stellenbosch : University of Stellenbosch, 2006-12)Early life trauma leads to behavioural abnormalities later in life. These include mood and anxiety disorders such as depression and posttraumatic stress disorder (PTSD). This association may be due in part to the effects ... -
Effects of insulin and leptin on human spermatozoa function and their cross-talk with nitric oxide and cytokines
(Stellenbosch : University of Stellenbosch, 2009-12)ENGLISH ABSTRACT: In recent years there has been an increase in obesity and diabetes mellitus (DM). These conditions have for a long time been associated with infertility. Obesity is characterized by high levels of ... -
Epacs exchange protein directly activated by cAMP role in obesity-induced cardiovascular diseases
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Introduction and aims: The strong association between obesity and cardiovascular diseases (CVD) stresses the necessity of elucidating the underlying molecular mechanisms linking these pathologies. ... -
Exposure of cardiac microvascular endothelial cells to harmful stimuli : a study of the cellular responses and mechanisms
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Exposure to harmful stimuli can render vascular endothelial cells dysfunctional, characterised by reduced nitric oxide (NO) bioavailibility. Endothelial dysfunction (ED) is a reversible precursor ... -
Gamete proteomic profile of male patients suffering from sexually transmitted infections
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: The aim of this study was to provide better insight into the effects of Neisseria gonorrhoea, Chlamydia trachomatis, and Trichomonas vaginalis on semen characteristics. In addition, a crucial focus was ... -
HIV/AIDS and air pollution as emerging cardiovascular risk factors in Cape Town populations : is endothelial function a marker of effect
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Background: HIV and antiretroviral therapy (ART) are associated with cardiovascular disease (CVD). Concomitantly,air pollution is a global health concern and associated with CVD. Although South Africa ... -
Hypoxia and the heart : the role of nitric oxide in cardiac myocytes and endothelial cells
(Stellenbosch : University of Stellenbosch, 2007-03)Nitric oxide (NO) is a major signaling molecule in the heart with various biological effects. The putative role of NO as a cardioprotective agent against ischaemiareperfusion injury and in ischaemic preconditioning (IP) ... -
Identification of novel DNA methylation signatures in the development of cardiovascular disease
(2021)ENGLISH ABSTRACT: Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, claiming approximately 17.9 million lives annually. The last few decades have seen an exponential increase in the prevalence ... -
Immunohaematopoietic stem and progenitor cell transplantation - a thirty year prospective and systematic research investigation
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: See full text for abstract
