Browsing Doctoral Degrees (Medical Physiology) by Title
Now showing items 1-20 of 31
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Basic semen parameters assisted by Computer-Aided sperm analysis (CASA) and their correlations with advanced semen parameters in normozoospermic men with different abstinence periods
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Affordable basic semen analysis remains a fundamental procedure to be performed routinely during the diagnosis of male infertility. Advanced semen analyses, provide valuable clinical insights in treatment ... -
Compounds specific to Aspalathus linearis protects the diabetic heart against oxidative stress: a mechanistic study
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT : In diabetics, hyperglycemia, hyperlipidemia and inflammation potentiates the development of cardiovascular diseases (CVDs). These conditions provoke excessive generation of oxidative stress that has been ... -
Contribution of highly active anti-retroviral therapy to the development of non-alcoholic fatty liver disease with concomitant cardiovascular dysfunction in an obese rat model
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: HIV/AIDS mortality is declining due to successful highly active anti-retroviral therapy (HAART). However, obesity, non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) in treated ... -
The dietary ionic effects on sex ratios in animal models
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: X-linked disorders are more expressed in male offspring and prevention of these hereditary diseases is the only recourse to date. Influencing conception towards female offspring can circumvent this problem; ... -
The effect of creatine supplementation on myocardial metabolism and function in sedentary and exercised rats
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Background: There has been a dramatic increase in the use of dietary creatine supplementation among sports men and women, and by clinicians as a therapeutic agent in muscular and neurological diseases. ... -
The effect of Cyclopia maculata extract on β-cell function, protection against oxidative stress and cell survival
(Stellenbosch : Stellenbosch University, 2014-12)ENGLISH ABSTRACT: Insights into the role of oxidative stress and pancreatic β-cell dysfunction in the pathogenesis of type 2 diabetes (T2D) reveals an opportunity for the development of novel therapeutics that directly ... -
Effect of different substrates on functional performance and kinase activation during reperfusion after ischaemia in hearts from obese insulin resistant rats
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Obesity is an important risk factor for the development of insulin resistance, the metabolic syndrome and diabetes and has also been implicated as one of the major risk factors for coronary heart disease. ... -
The effects of early life trauma on the neurochemistry and behaviour of the adult rat
(Stellenbosch : University of Stellenbosch, 2006-12)Early life trauma leads to behavioural abnormalities later in life. These include mood and anxiety disorders such as depression and posttraumatic stress disorder (PTSD). This association may be due in part to the effects ... -
Effects of insulin and leptin on human spermatozoa function and their cross-talk with nitric oxide and cytokines
(Stellenbosch : University of Stellenbosch, 2009-12)ENGLISH ABSTRACT: In recent years there has been an increase in obesity and diabetes mellitus (DM). These conditions have for a long time been associated with infertility. Obesity is characterized by high levels of ... -
Exposure of cardiac microvascular endothelial cells to harmful stimuli : a study of the cellular responses and mechanisms
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Exposure to harmful stimuli can render vascular endothelial cells dysfunctional, characterised by reduced nitric oxide (NO) bioavailibility. Endothelial dysfunction (ED) is a reversible precursor ... -
Gamete proteomic profile of male patients suffering from sexually transmitted infections
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: The aim of this study was to provide better insight into the effects of Neisseria gonorrhoea, Chlamydia trachomatis, and Trichomonas vaginalis on semen characteristics. In addition, a crucial focus was ... -
Hypoxia and the heart : the role of nitric oxide in cardiac myocytes and endothelial cells
(Stellenbosch : University of Stellenbosch, 2007-03)Nitric oxide (NO) is a major signaling molecule in the heart with various biological effects. The putative role of NO as a cardioprotective agent against ischaemiareperfusion injury and in ischaemic preconditioning (IP) ... -
Immunohaematopoietic stem and progenitor cell transplantation - a thirty year prospective and systematic research investigation
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: See full text for abstract -
The impact of developmental stress on the functioning and vulnerability of CNS neurons
(Stellenbosch : Stellenbosch University, 2008-12)The overall objective of this thesis is to provide additional data to assist clinicians and experimental neurologists alike in the quest for better understanding, more accurately diagnosing and more successfully treating ... -
The impact of obesity and chronic PPAR Alpha agonist treatment on cardiac function, metabolism and ischaemic tolerance
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Background: Myocardial oxidative fuel supply is increased in obese conditions. How this metabolic environment and altered cardiometabolic phenotype associated with prediabetic obesity impacts on cardiac ... -
Investigating the cholesterol-independent (pleiotropic) effects of selected hypolipidaemic agents in functional and dysfunctional endothelial cells
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: Vascular endothelium forms the first line of defence against harmful stimuli in the circulation. Endothelial dysfunction is a valuable predictor of cardiovascular disease and therapies aimed at improving ... -
An investigation into the anti-obesity properties of Cyclopia
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH SUMMARY: Polyphenols have a range of health promoting effects against chronic diseases such as obesity and type 2 diabetes mellitus. Previous research in our group showed that Cyclopia species (honeybush), endemic ... -
An investigation into the importance of the ATM protein in the myocardial pathology associated with insulin resistance and type 2 diabetes
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Introduction: Ataxia-telangiectasia (A-T) is an autosomal, recessive disorder that is caused by mutations in the ataxia-telangiectasia mutated (ATM) gene. The gene product, ATM, is a 350 kDa serine/threonine ... -
Investigation into the intracellular mechanisms whereby long-chain fatty acids protect the heart in ischaemia/reperfusion
(Stellenbosch : Stellenbosch University, 2005-03)ENGLISH ABSTRACT: Although there is evidence for a protective role of long-chain polyunsaturated fatty acids (PUFAs) in cardiovascular disease, their mechanism of action as well as their participation in intracellular ... -
An investigation into the role of ATM protein in mitochondrial defects associated with cardiovascular pathology resulting from insulin resistance
(Stellenbosch : Stellenbosch University, 2019-04)Background: Ataxia-telangiectasia (A-T) is a rare, recessive disorder that develops in the absence of Ataxia-Telangiectasia Mutated protein kinase (ATM). This complex disease is characterised by neurodegeneration, increased ...
