Masters Degrees (Medical Physiology): Recent submissions
Now showing items 1-20 of 83
-
The role of the intestinal immune system in the development and treatment of type 2 diabetes
(Stellenbosch : Stellenbosch University, 2022-11)ENGLISH ABSTRACT: Background: Type 2 diabetes (T2D) is largely correlated with obesity. Low-grade systemic inflammation and altered immune homeostasis in the gut are implicated in the pathogenesis of T2D. The intestinal ... -
The vascular and endothelial effects of HIV, antiretroviral therapy and rooibos - functional effects and mechanism
(Stellenbosch : Stellenbosch University, 2022-12)ENGLISH ABSTRACT: Individuals infected with human immunodeficiency virus-1 (HIV-1) are living longer but are at increased risk of cardiovascular disease (CVD). Antiretroviral therapy (ART) has been implicated in the ... -
Is there a combined dose-response effect of cigarette smoking and alcohol use during pregnancy on birth weight in a diverse western cape community of South Africa?
(Stellenbosch : Stellenbosch University, 2022-04)Introduction: Prenatal cigarette exposure (PCE) and prenatal alcohol exposure (PAE) are associated with obstetric complications such as intrauterine growth restriction. This could lead to small for gestational age (SGA) ... -
A mechanistic study on the mu-opioid receptor in human spermatozoa
(Stellenbosch : Stellenbosch University, 2021-12)Background: Infertility remains a complex and often unexplained phenomenon. The effect of opioids on male reproductive parameters is best understood by the suppression of the hypothalamic- pituitary-gonadal (HPG) axis. ... -
Cardio-metabolic risk profile of people living with HIV: Is retinal microvascular geometric morphology a marker of effect?
(Stellenbosch : Stellenbosch University, 2022-04)Background and Aim Cardiovascular disease in people living with HIV has become of great concern. HI-viral factors, ART-toxicity and HIV/ART-associated cardiometabolic adverse effects have been implicated in the development ... -
Factors that affect the adipocytic differentiation of adipose-derived mesenchymal stem cells
(Stellenbosch : Stellenbosch University, 2022-04)Background – Increased adiposity, particularly the accumulation of visceral adipose tissue is linked to the onset and progression of the metabolic syndrome. Despite the known pathogenicity of excessive visceral fat ... -
The effect of an aspalathin-rich rooibos extract on inflammatory crosstalk between adipocytes and muscle cells
(Stellenbosch : Stellenbosch University, 2021, 2021-12)ENGLISH ABSTRACT: The skeletal muscle not only plays a role in maintaining posture and generating force (contraction), but also is a dynamic metabolically active tissue that plays a central role in the regulation of ... -
Modeling changes in resting heart rate and its relationship to all-cause mortality in humans
(Stellenbosch : Stellenbosch University, 2021-03)Background Resting heart rate (RHR) is an easily measurable proxy of cardiovascular and general health. Extensive cohort studies have indicated that a higher RHR among individuals, results in an increased risk of all-cause ... -
The identification of the Dopamine Transporter (DAT) and the effects of dopamine on human sperm parameters
(Stellenbosch : Stellenbosch University, 2021-03)Thesis (MMed)--Stellenbosch University, 2021. -
Effect of rooibos treatment on inflammatory and oxidative stress genes in in vitro and in vivo models of NAFLD
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Background: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have been associated with the rise in metabolic diseases. Inflammation and oxidative stress are key mediators ... -
Antioxidant supplementation as protective strategy against stem cell impairment in Type 2 Diabetes
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Type 2 Diabetes Mellitus (T2DM) is a global epidemic. It is a complex disorder that leads to cellular dysfunction and the development of co-morbidities. The underlying pathologic microenvironment in T2DM, ... -
A potential link between adiposity and the heart: Investigating a posttranscriptional mechanism of cardiac ATM protein regulation in obesity
(Stellenbosch : Stellenbosch University, 2021-03)Background:Obesity isarisk factor for metabolic abnormalities,includinginsulin resistance, which precedes type II diabetes and cardiovascular diseases.White adipose tissue(WAT)isan endocrineorgan responsible for maintaining ... -
Investigating the efficacy and underlying mechanism of cardioprotection afforded by rooibos (aspalathus linearis) in angiotensin-ii induced cardiac hypertrophy & apoptosis
(Stellenbosch : Stellenbosch University, 2021-03)Purpose:Rooibos (RB) has been reported to confer cardioprotection, but the underlying mechanisms are not fully elucidated. Furthermore, RB has never been tested againstcardiac hypertrophy and apoptosis. ... -
Investigating the Modulating effects of Fermented Rooibos (Aspalathus linearis) and Fermented Honeybush (Cyclopia intermedia) on aortic endothelial function and antioxidant status in Streptozotocin (STZ) – induced diabetic Wistar rats
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Introduction: Diabetes mellitus is a metabolic disorder that causes chronic hyperglycaemia due to insulin resistance and deficiency. The implications that chronic hyperglycaemia has on vascular function ... -
Investigating the ameliorative potential of Aspalathus linearis and Cyclopia intermedia against lipid accumulation, lipolysis, oxidative stress and inflammation
(Stellenbosch : Stellenbosch University, 2020-03)Background Despite the availability of several treatment regimens, obesity continues to be one of the greatest health challenges of the 21st century. In recent years, plant polyphenols have attracted increasing attention ... -
Chronic stress and semen parameters
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: It has been well documented that stress has adverse effects on the body and can lead to various health issues. Stress has been investigated as a cause for unexplained infertility in both men and women. ... -
Investigating the effect of simulated Ischemia on phosphatases : comparing a cardiomyocytes (H9c2) cell line with a breast cancer (MDA-MB 231) cell line
(Stellenbosch : Stellenbosch University, 2020-03)Background: Reversible phosphorylation is responsible for an estimated 30% of protein regulation. Protein phosphorylation is catalysed by protein kinases and dephosphorylation by protein phosphatases. Ischemia, which is ... -
Observing the Effects of Anxiety Levels on Male Reproductive Parameters
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Literature presents a complex and often contradictory picture of the link between psychological stress and male fertility. Very limited information is available on the specific relationship between anxiety ... -
The effect of lipid modifying drugs on male reproductive parameters
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: The risk of cardiovascular disease (CVD) is prevalent and on the increase globally. Lipid-lowering drugs, have been found to reduce CVD. They act by either reducing LDL or increasing HDL. Thus reducing ... -
Quantification of positron emission tomography brain imaging using 18F-Fallypride: a simulation
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: 18F-fallypride is of interest in neurological and psychiatric diseases to visualise dopamine D2/D3 receptors in striatal and extrastriatal regions. Several simplified methods of quantifying positron ...
