Masters Degrees (Medical Physiology): Recent submissions
Now showing items 1-20 of 66
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Observing the Effects of Anxiety Levels on Male Reproductive Parameters
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Literature presents a complex and often contradictory picture of the link between psychological stress and male fertility. Very limited information is available on the specific relationship between anxiety ... -
The effect of lipid modifying drugs on male reproductive parameters
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: The risk of cardiovascular disease (CVD) is prevalent and on the increase globally. Lipid-lowering drugs, have been found to reduce CVD. They act by either reducing LDL or increasing HDL. Thus reducing ... -
Quantification of positron emission tomography brain imaging using 18F-Fallypride: a simulation
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: 18F-fallypride is of interest in neurological and psychiatric diseases to visualise dopamine D2/D3 receptors in striatal and extrastriatal regions. Several simplified methods of quantifying positron ... -
ATM Expression in peripheral blood mononuclear cells as a biomarker of insulin resistance
(Stellenbosch : Stellenbosch University, 2019-04)Introduction: The Ataxia Telangiectasia Mutated (ATM) gene codes for the 350 kDa ATM protein kinase. ATM gene mutations cause inactivity/deficiency of the ATM protein, resulting in the autosomal recessive disease Ataxia ... -
Investigating the onset of insulin resistance and non-alcoholic fatty liver disease in obesity-induced cardiac dysfunction
(Stellenbosch : Stellenbosch University, 2019-04)Introduction: The global obesity epidemic has been associated with various metabolic disorders, including insulin resistance and non-alcoholic fatty liver disease (NAFLD). Insulin resistance is thought be a hallmark of ... -
The Effects of HIV-1-proteins and Antiretroviral Therapy on Aortic Endothelial Cells (AECs) – A Mechanistic in vitro Approach
(Stellenbosch : Stellenbosch University, 2019-04)Introduction: Endothelial dysfunction is an early precursor of cardiovascular disease characterized by decreased nitric oxide (NO) levels following the development of oxidative stress. Oxidative stress has been shown to ... -
In vitro assessment of aspalathin-enriched Rooibos (Aspalathus linearis) extract treatment in statin-induced hepatotoxicity
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Rooibos (Aspalathus linearis) has been shown to have various health benefits including antidiabetic, lipid-lowering, and hepatoprotective properties. Although anecdotally Rooibos consumption is regarded ... -
Investigating the modulating effects of Afriplex GRT Extract on vascular function and antioxidant status in obese Wistar rat
(Stellenbosch : Stellenbosch University, 2018-03)Introduction Obesity is associated with the development of metabolic syndrome, a conglomerate of cardiometabolic risk factors, which synergistically result in cardiovascular diseases (CVDs), the major leading cause of ... -
The effects of melatonin supplementation on vascular tissue during first line ART: an in vivo, ex vivo and in vitro study
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Although Antiretroviral therapy (ART) has dramatically reduced HIVassociated morbidity and mortality, non-HIV-related conditions and comorbidities continue to rise in this population. Cardiovascular disease ... -
The effect of hypoxia on protein phosphatase 2A (PP2A) in MDA-MB-231 cells, and, a pilot study to establish a primary breast cancer cell model from Fine Needle Aspirations.
(Stellenbosch : Stellenbosch University, 2018-03)Background: Cancerous tumours are characterised by areas of insufficient blood supply, with resulting hypoxia and nutrient deprivation. The mechanisms by which cancer cells adapt to these conditions are of interest due ... -
The Significance of Mitophagy in Myocardial Ischaemia/ Reperfusion: the effect of melatonin
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Myocardial ischaemia and concomitant cell damage are caused by a reduction in the blood supply to the heart. To date, the most effective strategy to salvage the myocardium is timely reperfusion which is ... -
Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Various studies have sought to determine the typical versus optimal abstinence period after which semen samples should be collected, and many have been found to be contradictory. Several factors influence ... -
The effect of chronic ingestion of afriplex grt™ on myocardial insulin resistance and mitochondrial function – a preclinical study.
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Obesity is an excessive fat accumulation in the body, known to be a significant precursor to insulin resistance and type 2 diabetes. Complications associated with obesity can contribute to the development of ... -
Stem cell impairment associated with type 2 diabetes mellitus : investigating the effects of obesity-associated inflammation on mesenchymal stem cell function
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT : Background: South Africa has the highest prevalence of obesity in sub-Saharan Africa, particularly in Black women. This population is thus at a higher risk of developing obesity-associated type 2 diabetes ... -
Investigating the effects of first line and second line antiretroviral drugs on HIV exposed endothelial function - A clinical study, supported by a mechanistic in-vitro approach
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Background: There is an interaction between HIV, antiretroviral treatment (ART) and endothelial dysfunction; furthermore, HIV-infected individuals (± ART) show an increased incidence of cardiovascular ... -
Effect of Aspalathus linearis supplementation, during anti-retroviral treatment, on the heart and aortas of male Wistar rats and the effects of drinking rooibos on the cardiovascular profile of patients on ART.
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Introduction Improved survival rates in the human immunodeficiency virus (HIV) population, due to the use of antiretroviral therapy (ART), are associated with increased risk for cardiovascular disease ... -
The role of mitophagy in damage incurred by ischaemia/reperfusion
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Background and aims: Mitophagy is a specialised process of autophagy whereby dysfunctional mitochondria are removed. Mitophagy has been increasingly recognised as an essential process to sustain a healthy ... -
The treatment effect of Rooibos on vascular function and signalling pathways of aortas from diet induced obese rats.
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Introduction: Obesity is becoming a worldwide health problem and is a well-documented independent risk factor for the development of endothelial dysfunction (decreased nitric oxide (NO) bioavailability) ... -
Optimization of experimental conditions and analysis tools for the study of phosphodiesterase-5 in a model of cultured adult rat cardiomyocytes
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Part 1 Introduction: Phosphodiesterases (PDEs) hydrolyse cyclic nucleotides that regulate ischemia-reperfusion injury (IRI) in the heart. Phosphodiesterases-5 (PDE5) inhibition increases cyclic guanosine ... -
The role of Phosphodiesterase 4 in insulin- and phytocannabinoids-induced cardio-protection, and B-adrenergic cardiac damage.
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: Introduction: Cardiovascular disease (CVD) is one of the main non-communicable diseases globally contributing to deaths each year. Ischemic heart disease leading to myocardial infarction (or heart attack ...
