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Investigating the onset of insulin resistance and non-alcoholic fatty liver disease in obesity-induced cardiac dysfunction
(Stellenbosch : Stellenbosch University, 2019-04)
Introduction: The global obesity epidemic has been associated with various metabolic disorders, including insulin resistance and non-alcoholic fatty liver disease (NAFLD). Insulin resistance is thought be a hallmark of ...
ATM Expression in peripheral blood mononuclear cells as a biomarker of insulin resistance
(Stellenbosch : Stellenbosch University, 2019-04)
Introduction: The Ataxia Telangiectasia Mutated (ATM) gene codes for the 350 kDa ATM protein kinase. ATM gene mutations cause inactivity/deficiency of the ATM protein, resulting in the autosomal recessive disease Ataxia ...