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    The impact of activation of the renin-angiotensin system in the development of insulin resistance in experimental models of obesity 

    Perel, Shireen J. C. (Stellenbosch : University of Stellenbosch, 2009-03)
    Insulin stimulates the production of nitric oxide (NO) in endothelial cells and cardiac myocytes by a signalling pathway that involves the insulin receptor substrate (IRS)-1, phosphatidylinositol-3-kinase and protein ...
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    A pathologic role for angiotensin II and endothelin-1 in cardiac remodelling and ischaemia and reperfusion injury in a rat model of the metabolic syndrome 

    Smith, Wayne (Stellenbosch : University of Stellenbosch, 2006-03)
    Introduction: Obesity, which is implicated in the development of the metabolic syndrome (MS) is reaching epidemic proportions worldwide. MS significantly increases the risk of developing cardiovascular disease, which ...
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    The role of glycogen synthase kinase-3 (GSK-3) protein in the development of myocardial hypertrophy in a rat model of diet induced obesity and insulin resistance 

    Lubelwana Hafver, Tandekile (Stellenbosch : Stellenbosch University, 2012-03)
    ENGLISH ABSTRACT: Introduction: The worldwide escalation in the incidence of obesity and its strong association with insulin resistance, type 2 diabetes and the cardiovascular complications that accompany these disease ...
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    Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity : an in vivo and ex vivo approach 

    Everson, Frans Pieter (Stellenbosch : Stellenbosch University, 2016-03)
    ENGLISH ABSTRACT: Introduction: An interaction exists between cardiovascular risk factors (e.g. obesity) and antiretroviral treatment (ART) in the pathogenesis of cardiovascular disease. While ART reverses HIV- related ...
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    The role of Atm in the regulation of cardiomyocyte glucose utilization under normal and insulin resistant conditions 

    Van Vuuren, Mignon (Stellenbosch : Stellenbosch University, 2016-03)
    ENGLISH ABSTRACT: Introduction: Ataxia-telangiectasia (A-T) is an autosomal, recessive disorder that progressively affects multiple organs. A-T is caused by mutations in the Atm gene (ataxia-telangiectasia mutated gene), ...
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    A study of the early changes in hearts from diet-induced obese rats that may lead to cardiac dysfunction 

    Bezuidenhout, Nicole Joy (Stellenbosch : University of StellenboschStellenbosch : University of Stellenbosch, 2011-03)
    ENGLISH ABSTRACT: INTRODUCTION: Obesity and its associated complications such as diabetes and cardiovascular disease are escalating worldwide. Cardiovascular mortality and the occurrence of heart failure following a ...
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    Investigating the onset of insulin resistance and non-alcoholic fatty liver disease in obesity-induced cardiac dysfunction 

    Boshoff, Anel W. (Stellenbosch : Stellenbosch University, 2019-04)
    Introduction: The global obesity epidemic has been associated with various metabolic disorders, including insulin resistance and non-alcoholic fatty liver disease (NAFLD). Insulin resistance is thought be a hallmark of ...
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    Role of glycogen synthase kinase 3 (GSK-3) and its substrate proteins in the development of cardiomyopathy associated with obesity and insulin resistance 

    Flepisi, Thabile Brian (Stellenbosch : University of Stellenbosch, 2011-03)
    ENGLISH ABSTRACT: INTRODUCTION: Glycogen synthase kinase-3 (GSK-3) is a serine-threonine protein kinase that was first discovered as a regulator of glycogen synthase thus playing a role in glycogen synthesis (Embi et al. ...
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    A potential link between adiposity and the heart: Investigating a posttranscriptional mechanism of cardiac ATM protein regulation in obesity 

    Botha, Danelle (Stellenbosch : Stellenbosch University, 2021-03)
    Background:Obesity isarisk factor for metabolic abnormalities,includinginsulin resistance, which precedes type II diabetes and cardiovascular diseases.White adipose tissue(WAT)isan endocrineorgan responsible for maintaining ...

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    AuthorBezuidenhout, Nicole Joy (1)Boshoff, Anel W. (1)Botha, Danelle (1)Everson, Frans Pieter (1)Flepisi, Thabile Brian (1)Lubelwana Hafver, Tandekile (1)Perel, Shireen J. C. (1)Smith, Wayne (1)Van Vuuren, Mignon (1)Subject
    Obesity (9)
    Dissertations -- Medical physiology (4)Theses -- Medical physiology (4)UCTD (4)Biomedical Sciences (3)Insulin resistance (3)Angiotensin II (2)Ataxia telangiectasia (2)Cardiovascular system -- Diseases (2)Dissertations -- Medicine (2)... View MoreDate Issued2020 - 2021 (1)2010 - 2019 (6)2006 - 2009 (2)Has File(s)Yes (9)
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