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The impact of activation of the renin-angiotensin system in the development of insulin resistance in experimental models of obesity
(Stellenbosch : University of Stellenbosch, 2009-03)
Insulin stimulates the production of nitric oxide (NO) in endothelial cells and cardiac
myocytes by a signalling pathway that involves the insulin receptor substrate (IRS)-1,
phosphatidylinositol-3-kinase and protein ...
A pathologic role for angiotensin II and endothelin-1 in cardiac remodelling and ischaemia and reperfusion injury in a rat model of the metabolic syndrome
(Stellenbosch : University of Stellenbosch, 2006-03)
Introduction: Obesity, which is implicated in the development of the metabolic
syndrome (MS) is reaching epidemic proportions worldwide. MS significantly
increases the risk of developing cardiovascular disease, which ...
The role of glycogen synthase kinase-3 (GSK-3) protein in the development of myocardial hypertrophy in a rat model of diet induced obesity and insulin resistance
(Stellenbosch : Stellenbosch University, 2012-03)
ENGLISH ABSTRACT: Introduction: The worldwide escalation in the incidence of obesity and its strong association
with insulin resistance, type 2 diabetes and the cardiovascular complications that accompany
these disease ...
Role of glycogen synthase kinase 3 (GSK-3) and its substrate proteins in the development of cardiomyopathy associated with obesity and insulin resistance
(Stellenbosch : University of Stellenbosch, 2011-03)
ENGLISH ABSTRACT: INTRODUCTION: Glycogen synthase kinase-3 (GSK-3) is a serine-threonine protein kinase that was first discovered as a regulator of glycogen synthase thus playing a role in glycogen synthesis (Embi et al. ...
Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity : an in vivo and ex vivo approach
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT: Introduction:
An interaction exists between cardiovascular risk factors (e.g. obesity) and antiretroviral treatment (ART) in the pathogenesis of cardiovascular disease. While ART reverses HIV- related ...
The role of Atm in the regulation of cardiomyocyte glucose utilization under normal and insulin resistant conditions
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT: Introduction: Ataxia-telangiectasia (A-T) is an autosomal, recessive disorder that progressively affects multiple organs. A-T is caused by mutations in the Atm gene (ataxia-telangiectasia mutated gene), ...
A study of the early changes in hearts from diet-induced obese rats that may lead to cardiac dysfunction
(Stellenbosch : University of StellenboschStellenbosch : University of Stellenbosch, 2011-03)
ENGLISH ABSTRACT: INTRODUCTION: Obesity and its associated complications such as diabetes and cardiovascular disease are escalating worldwide. Cardiovascular mortality and the occurrence of heart failure following a ...
Investigating the onset of insulin resistance and non-alcoholic fatty liver disease in obesity-induced cardiac dysfunction
(Stellenbosch : Stellenbosch University, 2019-04)
Introduction: The global obesity epidemic has been associated with various metabolic disorders, including insulin resistance and non-alcoholic fatty liver disease (NAFLD). Insulin resistance is thought be a hallmark of ...