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The role of glycogen synthase kinase-3 (GSK-3) protein in the development of myocardial hypertrophy in a rat model of diet induced obesity and insulin resistance

Lubelwana Hafver, Tandekile (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Introduction: The worldwide escalation in the incidence of obesity and its strong association with insulin resistance, type 2 diabetes and the cardiovascular complications that accompany these disease ...

The effect of CPT-1 inhibition on myocardial function and resistance to ischemia/reperfusion injury in a rodent model of the metabolic syndrome

Maarman, Gerald Jerome (Stellenbosch : University of Stellenbosch, 2010-12)

ENGLISH ABSTRACT: Background: Obesity is associated with dyslipidemia, insulin resistance and glucose intolerance and together these components characterise the metabolic syndrome (Dandona et al. 2005). In the state of ...

A critical analysis of mitochondrial functioning and associated proteins in obesity-related cardiomyopathy

George, Siddiqah (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: INTRODUCTION: The mechanism behind obesity-related cardiomyopathies is at present not completely known, however, cardiac insulin resistance has been implicated as one of the main arbitrators of obesity-related ...

An investigation into the effects of aspalathin on myocardial glucose transport using cardiomyocytes from control and obesity-induced insulin resistant rats, and terminally differentiated H9C2 cells

Smit, Sybrand Engelbrecht (Stellenbosch : Stellenbosch University, 2016-03)

ENGLISH ABSTRACT: Introduction: Rooibos is an indigenous South African plant ingested as herbal tea and well-known for its strong anti-oxidant effects. Rooibos has shown to have cardioprotective properties in vitro and ...

The role of Atm in the regulation of cardiomyocyte glucose utilization under normal and insulin resistant conditions

Van Vuuren, Mignon (Stellenbosch : Stellenbosch University, 2016-03)

ENGLISH ABSTRACT: Introduction: Ataxia-telangiectasia (A-T) is an autosomal, recessive disorder that progressively affects multiple organs. A-T is caused by mutations in the Atm gene (ataxia-telangiectasia mutated gene), ...

Investigating the onset of insulin resistance and non-alcoholic fatty liver disease in obesity-induced cardiac dysfunction

Boshoff, Anel W. (Stellenbosch : Stellenbosch University, 2019-04)

Introduction: The global obesity epidemic has been associated with various metabolic disorders, including insulin resistance and non-alcoholic fatty liver disease (NAFLD). Insulin resistance is thought be a hallmark of ...

ATM Expression in peripheral blood mononuclear cells as a biomarker of insulin resistance

Williams, Lois Esther (Stellenbosch : Stellenbosch University, 2019-04)

Introduction: The Ataxia Telangiectasia Mutated (ATM) gene codes for the 350 kDa ATM protein kinase. ATM gene mutations cause inactivity/deficiency of the ATM protein, resulting in the autosomal recessive disease Ataxia ...

The efficacy of Diavite tm (Prosopis glandulosa) as anti-diabetic treatment in rat models of streptozotocin-induced type 1 diabetes and diet-induced-obese insulin resistance

Hill, Cindy (Stellenbosch : University of Stellenbosch, 2010-03)

ENGLISH ABSTRACT: Introduction: Obesity and its associated complications, such as the metabolic syndrome, hypertension and cardiovascular disease, are escalating worldwide. In recognition of this, untested remedies advertised ...

The effects of chronic melatonin treatment on myocardial function and ischaemia and reperfusion injury in a rat model of diet-induced obesity

Nduhirabandi, Frederic (Stellenbosch : Stellenbosch University, 2010-03)

ENGLISH ABSTRACT: Obesity is a major risk factor for ischaemic heart disease. Obesity-induced metabolic abnormalities have been associated with increased oxidative stress which may play an important role in the increased ...

The effect of an aspalathin-rich rooibos extract on inflammatory crosstalk between adipocytes and muscle cells

Obonye, Nnini (Stellenbosch : Stellenbosch University, 2021, 2021-12)

ENGLISH ABSTRACT: The skeletal muscle not only plays a role in maintaining posture and generating force (contraction), but also is a dynamic metabolically active tissue that plays a central role in the regulation of ...