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The impact of activation of the renin-angiotensin system in the development of insulin resistance in experimental models of obesity
(Stellenbosch : University of Stellenbosch, 2009-03)
Insulin stimulates the production of nitric oxide (NO) in endothelial cells and cardiac
myocytes by a signalling pathway that involves the insulin receptor substrate (IRS)-1,
phosphatidylinositol-3-kinase and protein ...
A comparison of motility and head morphology of sperm using different semen processing methods and three different staining techniques
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: Sperm morphology remains an important parameter in the prediction of fertility, both
in vivo and in vitro. However, there remains a considerable level of concern
surrounding the true potential of this ...
The effect of CPT-1 inhibition on myocardial function and resistance to ischemia/reperfusion injury in a rodent model of the metabolic syndrome
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: Background: Obesity is associated with dyslipidemia, insulin resistance and glucose intolerance and together these components characterise the metabolic syndrome (Dandona et al. 2005). In the state of ...
Measurement of free radicals and their effects on human spermatozoa
(Stellenbosch : University of Stellenbosch, 2006-03)
In this study, we presented data on the role of free radicals in human spermatozoa, particularly in the context of centrifugation and the potential development of defective sperm function. In order to achieve this, methods ...
The effects of physical and psychological stress on the behaviour and neurochemistry of rats
(Stellenbosch : University of Stellenbosch, 2005-12)
Stress is considered one of the major factors involved in the pathogenesis of affective disorders, for example, direct and indirect exposure to terrorist attacks or being subjected to subtle victimization. There is a long ...
Acrosome size and kinematics of human spermatozoa
(Stellenbosch : University of Stellenbosch, 2007-03)
For spermatozoa to gain access to the oocyte for fertilization, lytic enzymes need to
be released during the acrosome reaction. These enzymes, which are stored and
transported within an organelle termed the acrosome, ...
A study of the early changes in hearts from diet-induced obese rats that may lead to cardiac dysfunction
(Stellenbosch : University of StellenboschStellenbosch : University of Stellenbosch, 2011-03)
ENGLISH ABSTRACT: INTRODUCTION: Obesity and its associated complications such as diabetes and cardiovascular disease are escalating worldwide. Cardiovascular mortality and the occurrence of heart failure following a ...
Role of glycogen synthase kinase 3 (GSK-3) and its substrate proteins in the development of cardiomyopathy associated with obesity and insulin resistance
(Stellenbosch : University of Stellenbosch, 2011-03)
ENGLISH ABSTRACT: INTRODUCTION: Glycogen synthase kinase-3 (GSK-3) is a serine-threonine protein kinase that was first discovered as a regulator of glycogen synthase thus playing a role in glycogen synthesis (Embi et al. ...