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Investigating the Modulating effects of Fermented Rooibos (Aspalathus linearis) and Fermented Honeybush (Cyclopia intermedia) on aortic endothelial function and antioxidant status in Streptozotocin (STZ) – induced diabetic Wistar rats
(Stellenbosch : Stellenbosch University, 2020-03)
ENGLISH ABSTRACT: Introduction: Diabetes mellitus is a metabolic disorder that causes chronic hyperglycaemia due to insulin resistance and deficiency. The implications that chronic hyperglycaemia has on vascular function ...
Investigating the effect of simulated Ischemia on phosphatases : comparing a cardiomyocytes (H9c2) cell line with a breast cancer (MDA-MB 231) cell line
(Stellenbosch : Stellenbosch University, 2020-03)
Background: Reversible phosphorylation is responsible for an estimated 30% of protein regulation. Protein phosphorylation is catalysed by protein kinases and dephosphorylation by protein phosphatases. Ischemia, which is ...
Chronic stress and semen parameters
(Stellenbosch : Stellenbosch University, 2020-03)
ENGLISH ABSTRACT: It has been well documented that stress has adverse effects on the body and can lead to various health issues. Stress has been investigated as a cause for unexplained infertility in both men and women. ...
Investigating the ameliorative potential of Aspalathus linearis and Cyclopia intermedia against lipid accumulation, lipolysis, oxidative stress and inflammation
(Stellenbosch : Stellenbosch University, 2020-03)
Background
Despite the availability of several treatment regimens, obesity continues to be one of the greatest health challenges of the 21st century. In recent years, plant polyphenols have attracted increasing attention ...
Effect of rooibos treatment on inflammatory and oxidative stress genes in in vitro and in vivo models of NAFLD
(Stellenbosch : Stellenbosch University, 2021-03)
ENGLISH ABSTRACT: Background: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have been associated with the rise in metabolic diseases. Inflammation and oxidative stress are key mediators ...
A potential link between adiposity and the heart: Investigating a posttranscriptional mechanism of cardiac ATM protein regulation in obesity
(Stellenbosch : Stellenbosch University, 2021-03)
Background:Obesity isarisk factor for metabolic abnormalities,includinginsulin resistance, which precedes type II diabetes and cardiovascular diseases.White adipose tissue(WAT)isan endocrineorgan responsible for maintaining ...
Investigating the efficacy and underlying mechanism of cardioprotection afforded by rooibos (aspalathus linearis) in angiotensin-ii induced cardiac hypertrophy & apoptosis
(Stellenbosch : Stellenbosch University, 2021-03)
Purpose:Rooibos (RB) has been reported to confer cardioprotection, but the underlying mechanisms are not fully elucidated. Furthermore, RB has never been tested againstcardiac hypertrophy and apoptosis. ...
The identification of the Dopamine Transporter (DAT) and the effects of dopamine on human sperm parameters
(Stellenbosch : Stellenbosch University, 2021-03)
Thesis (MMed)--Stellenbosch University, 2021.
Modeling changes in resting heart rate and its relationship to all-cause mortality in humans
(Stellenbosch : Stellenbosch University, 2021-03)
Background
Resting heart rate (RHR) is an easily measurable proxy of cardiovascular and general health.
Extensive cohort studies have indicated that a higher RHR among individuals, results in an
increased risk of all-cause ...
Factors that affect the adipocytic differentiation of adipose-derived mesenchymal stem cells
(Stellenbosch : Stellenbosch University, 2022-04)
Background –
Increased adiposity, particularly the accumulation of visceral adipose tissue is linked to the onset
and progression of the metabolic syndrome. Despite the known pathogenicity of excessive visceral
fat ...