Browsing Masters Degrees (Medical Physiology) by Title
Now showing items 41-60 of 70
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An investigation into the effects of aspalathin on myocardial glucose transport using cardiomyocytes from control and obesity-induced insulin resistant rats, and terminally differentiated H9C2 cells
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: Rooibos is an indigenous South African plant ingested as herbal tea and well-known for its strong anti-oxidant effects. Rooibos has shown to have cardioprotective properties in vitro and ... -
An investigation of the importance of the ATM protein in the endothelium and its role in the signalling pathways of NO production
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Ataxia telangiectasia (AT) is a well-characterized neurodegenerative disease resulting from a genetic defect in the Atm gene causing an absence or very low expression of the ATM protein. As AT patients ... -
Measurement of free radicals and their effects on human spermatozoa
(Stellenbosch : University of Stellenbosch, 2006-03)In this study, we presented data on the role of free radicals in human spermatozoa, particularly in the context of centrifugation and the potential development of defective sperm function. In order to achieve this, methods ... -
Nitric oxide and the endothelium : characterisation of in vitro nitric oxide detection techniques and an ex vivo method of measuring endothelial function
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Introduction: Nitric oxide (NO) is an important chemical messenger in the cardiovascular system. Despite considerable progress in this field, there remains an on-going need for affordable and user-friendly ... -
Observing the Effects of Anxiety Levels on Male Reproductive Parameters
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Literature presents a complex and often contradictory picture of the link between psychological stress and male fertility. Very limited information is available on the specific relationship between anxiety ... -
Optimization of experimental conditions and analysis tools for the study of phosphodiesterase-5 in a model of cultured adult rat cardiomyocytes
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Part 1 Introduction: Phosphodiesterases (PDEs) hydrolyse cyclic nucleotides that regulate ischemia-reperfusion injury (IRI) in the heart. Phosphodiesterases-5 (PDE5) inhibition increases cyclic guanosine ... -
A pathologic role for angiotensin II and endothelin-1 in cardiac remodelling and ischaemia and reperfusion injury in a rat model of the metabolic syndrome
(Stellenbosch : University of Stellenbosch, 2006-03)Introduction: Obesity, which is implicated in the development of the metabolic syndrome (MS) is reaching epidemic proportions worldwide. MS significantly increases the risk of developing cardiovascular disease, which ... -
The phenomenon of 'second window of protection' : effect of beta-adrenergic stimulation and melatonin
(Stellenbosch : Stellenbosch University, 2004-03)ENGLISH ABSTRACT: Please see fulltext for abstract. -
Possible mechanisms for levosimendaninduced cardioprotection
(Stellenbosch : Stellenbosch University, 2008-12)Background and purpose. To limit ischaemic injury, rapid restoration of coronary blood flow is required, which will in turn reduce infarct size. However, reperfusion itself causes myocyte death – a phenomenon termed ... -
Postconditioning the isolated perfused rat heart : the role of kinases and phosphatases
(Stellenbosch : Stellenbosch University, 2008-03)ENGLISH ABSTRACT: It has recently been observed that the application of multiple short cycles of reperfusion and ischaemia, at the onset of reperfusion, elicits cardioprotection against injury due to prior sustained ... -
Proteomic analysis of human sperm proteins in relation to sperm motility, morphology and energy metabolism
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Male infertility is often associated with impaired sperm motility and morphology (asthenoteratozoospermia) for which there is no specific therapeutic treatment. It has come to light that the modification ... -
A proteomic analysis of the ventral and dorsal hippocampal brain areas of serotonin knockout rats
(Stellenbosch : Stellenbosch University, 2008-03)For many centuries, scientists have engaged in a theoretical debate concerning the etiology of mood disorders, with very few ancient scholars speculating about the importance of genetic factors and affective temperaments ... -
Quantification of positron emission tomography brain imaging using 18F-Fallypride: a simulation
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: 18F-fallypride is of interest in neurological and psychiatric diseases to visualise dopamine D2/D3 receptors in striatal and extrastriatal regions. Several simplified methods of quantifying positron ... -
The relationship between respiratory muscle fatigue, core stability, kinanthropometric attributes and endurance performance in competitive kayakers
(Stellenbosch : University of Stellenbosch, 2005-03)The purpose of this study was to determine the physiological and kinanthropometric attributes, respiratory muscle strength, and core stability of successful endurance paddlers, and to investigate the associations of these ... -
The role of Atm in the regulation of cardiomyocyte glucose utilization under normal and insulin resistant conditions
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: Ataxia-telangiectasia (A-T) is an autosomal, recessive disorder that progressively affects multiple organs. A-T is caused by mutations in the Atm gene (ataxia-telangiectasia mutated gene), ... -
Role of glycogen synthase kinase 3 (GSK-3) and its substrate proteins in the development of cardiomyopathy associated with obesity and insulin resistance
(Stellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: INTRODUCTION: Glycogen synthase kinase-3 (GSK-3) is a serine-threonine protein kinase that was first discovered as a regulator of glycogen synthase thus playing a role in glycogen synthesis (Embi et al. ... -
The role of glycogen synthase kinase-3 (GSK-3) protein in the development of myocardial hypertrophy in a rat model of diet induced obesity and insulin resistance
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Introduction: The worldwide escalation in the incidence of obesity and its strong association with insulin resistance, type 2 diabetes and the cardiovascular complications that accompany these disease ... -
The role of mitophagy in damage incurred by ischaemia/reperfusion
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Background and aims: Mitophagy is a specialised process of autophagy whereby dysfunctional mitochondria are removed. Mitophagy has been increasingly recognised as an essential process to sustain a healthy ... -
The role of p38 MAPK activation in preconditioning mediated protection against ischaemia/reperfusion injury
(Stellenbosch : Stellenbosch University, 2002-12)ENGLISH ABSTRACT: The ultimate consequence of the interruption of blood flow to the myocardium is necrosis. In view of the prevalence of coronary artery disease in the general population, and the deleterious effects of ... -
The role of Phosphodiesterase 4 in insulin- and phytocannabinoids-induced cardio-protection, and B-adrenergic cardiac damage.
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: Introduction: Cardiovascular disease (CVD) is one of the main non-communicable diseases globally contributing to deaths each year. Ischemic heart disease leading to myocardial infarction (or heart attack ...
