Browsing Masters Degrees (Medical Physiology) by Title
Now showing items 1-20 of 70
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Abnormalities of bone and mineral metabolism in patients with eating disorders
(Stellenbosch : Stellenbosch University, 2001)ENGLISH ABSTRACT: Osteopenia is a well documented complication of anorexia nervosa (AN). The pathogenesis of this bone loss is presently poorly defined in the literature. Pathogenetic mechanisms that have been implicated ... -
Acrosome size and kinematics of human spermatozoa
(Stellenbosch : University of Stellenbosch, 2007-03)For spermatozoa to gain access to the oocyte for fertilization, lytic enzymes need to be released during the acrosome reaction. These enzymes, which are stored and transported within an organelle termed the acrosome, ... -
The anti-diabetic and insulin sensitizing potential of a watery extract of Agathosma tested in rat models of type 1 and type 2 diabetes
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH SUMMARY: Introduction: Epidemiological data highlights that South Africa is currently facing a quadruple burden of disease of which non-communicable diseases (NCDs) are estimated to account for 29% of all deaths. ... -
ATM Expression in peripheral blood mononuclear cells as a biomarker of insulin resistance
(Stellenbosch : Stellenbosch University, 2019-04)Introduction: The Ataxia Telangiectasia Mutated (ATM) gene codes for the 350 kDa ATM protein kinase. ATM gene mutations cause inactivity/deficiency of the ATM protein, resulting in the autosomal recessive disease Ataxia ... -
Changes in hyo-laryngeal elevation post-pharyngeal electrical stimulation
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Swallowing disorders are prevalent in many elderly individuals and are common amongst individuals suffering from neurological diseases. These individuals are affected from slight swallowing difficulty to ... -
Characterization of a sonified peak flow monitor
(Stellenbosch : University of Stellenbosch, 2000-03)ENGLISH ABSTRACT: The Whistle Watch™, an innovative and commercialised peak flow monitor, inspired this study, with its abnormal and complex measuring behaviour. The Whistle Watch™ latter is an audible peak flow monitor ... -
Chronic stress and semen parameters
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: It has been well documented that stress has adverse effects on the body and can lead to various health issues. Stress has been investigated as a cause for unexplained infertility in both men and women. ... -
A comparison of motility and head morphology of sperm using different semen processing methods and three different staining techniques
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Sperm morphology remains an important parameter in the prediction of fertility, both in vivo and in vitro. However, there remains a considerable level of concern surrounding the true potential of this ... -
A critical analysis of mitochondrial functioning and associated proteins in obesity-related cardiomyopathy
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: INTRODUCTION: The mechanism behind obesity-related cardiomyopathies is at present not completely known, however, cardiac insulin resistance has been implicated as one of the main arbitrators of obesity-related ... -
A diffusion tensor imaging study in HIV patients with and without apathy
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: HIV/AIDS is a global epidemic that accounts for a large percentage of the mortality in South Africa every year. Since the implementation of anti-retroviral treatment, HIV positive individuals have been ... -
The effect of 5'-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and 5'-aminoimidazole-4-carboxamide-ribonucleoside-phosphate (ZMP) on myocardial glucose uptake
(Stellenbosch : Stellenbosch University, 2005-03)ENGLISH ABSTRACT: Introduction: Exercise increases skeletal muscle glucose uptake via AMP-activated protein kinase (AMPK) activation and GLUT4 translocation from cytosol to cell membrane. It also promotes glucose ... -
Effect of Aspalathus linearis supplementation, during anti-retroviral treatment, on the heart and aortas of male Wistar rats and the effects of drinking rooibos on the cardiovascular profile of patients on ART.
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Introduction Improved survival rates in the human immunodeficiency virus (HIV) population, due to the use of antiretroviral therapy (ART), are associated with increased risk for cardiovascular disease ... -
The effect of chronic ingestion of afriplex grt™ on myocardial insulin resistance and mitochondrial function – a preclinical study.
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Obesity is an excessive fat accumulation in the body, known to be a significant precursor to insulin resistance and type 2 diabetes. Complications associated with obesity can contribute to the development of ... -
The effect of CPT-1 inhibition on myocardial function and resistance to ischemia/reperfusion injury in a rodent model of the metabolic syndrome
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Background: Obesity is associated with dyslipidemia, insulin resistance and glucose intolerance and together these components characterise the metabolic syndrome (Dandona et al. 2005). In the state of ... -
The effect of hypoxia on nitric oxide and endothelial nitric oxide synthase in the whole heart and isolated cardiac cells: the role of the PI3–K / PKB pathway as a possible mediator.
(Stellenbosch : University of Stellenbosch, 2009-03)In the heart, endothelial nitric oxide synthase (eNOS) is regarded as the most important constitutively expressed enzymatic source of nitric oxide (NO), a major cardiac signalling molecule. On the whole, NO is regarded ... -
The effect of hypoxia on protein phosphatase 2A (PP2A) in MDA-MB-231 cells, and, a pilot study to establish a primary breast cancer cell model from Fine Needle Aspirations.
(Stellenbosch : Stellenbosch University, 2018-03)Background: Cancerous tumours are characterised by areas of insufficient blood supply, with resulting hypoxia and nutrient deprivation. The mechanisms by which cancer cells adapt to these conditions are of interest due ... -
The effect of lipid modifying drugs on male reproductive parameters
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: The risk of cardiovascular disease (CVD) is prevalent and on the increase globally. Lipid-lowering drugs, have been found to reduce CVD. They act by either reducing LDL or increasing HDL. Thus reducing ... -
Effect of melatonin on myocardial susceptibility to ischaemia and reperfusion damage in a rat model of high-fat diet-induced obesity
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: Obesity has reached epidemic proportions worldwide and is currently a serious health problem. It is associated with metabolic abnormalities, oxidative stress, hypertension, insulin resistance and an ... -
The effects of a watery extract of Agathosma on the development of hypertension
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Introduction: Obesity is a major risk factor for non-communicable diseases (NCD), a collective term given to type 2 diabetes (T2D), hypertension (HTN) and cardiovascular disease (CVD). Globally, NCDs are ... -
The effects of chronic melatonin treatment on myocardial function and ischaemia and reperfusion injury in a rat model of diet-induced obesity
(Stellenbosch : Stellenbosch University, 2010-03)ENGLISH ABSTRACT: Obesity is a major risk factor for ischaemic heart disease. Obesity-induced metabolic abnormalities have been associated with increased oxidative stress which may play an important role in the increased ...
