Browsing Masters Degrees (Medical Physiology) by Title
Now showing items 49-68 of 70
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Possible mechanisms for levosimendaninduced cardioprotection
(Stellenbosch : Stellenbosch University, 2008-12)Background and purpose. To limit ischaemic injury, rapid restoration of coronary blood flow is required, which will in turn reduce infarct size. However, reperfusion itself causes myocyte death – a phenomenon termed ... -
Postconditioning the isolated perfused rat heart : the role of kinases and phosphatases
(Stellenbosch : Stellenbosch University, 2008-03)ENGLISH ABSTRACT: It has recently been observed that the application of multiple short cycles of reperfusion and ischaemia, at the onset of reperfusion, elicits cardioprotection against injury due to prior sustained ... -
Proteomic analysis of human sperm proteins in relation to sperm motility, morphology and energy metabolism
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Male infertility is often associated with impaired sperm motility and morphology (asthenoteratozoospermia) for which there is no specific therapeutic treatment. It has come to light that the modification ... -
A proteomic analysis of the ventral and dorsal hippocampal brain areas of serotonin knockout rats
(Stellenbosch : Stellenbosch University, 2008-03)For many centuries, scientists have engaged in a theoretical debate concerning the etiology of mood disorders, with very few ancient scholars speculating about the importance of genetic factors and affective temperaments ... -
Quantification of positron emission tomography brain imaging using 18F-Fallypride: a simulation
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: 18F-fallypride is of interest in neurological and psychiatric diseases to visualise dopamine D2/D3 receptors in striatal and extrastriatal regions. Several simplified methods of quantifying positron ... -
The relationship between respiratory muscle fatigue, core stability, kinanthropometric attributes and endurance performance in competitive kayakers
(Stellenbosch : University of Stellenbosch, 2005-03)The purpose of this study was to determine the physiological and kinanthropometric attributes, respiratory muscle strength, and core stability of successful endurance paddlers, and to investigate the associations of these ... -
The role of Atm in the regulation of cardiomyocyte glucose utilization under normal and insulin resistant conditions
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: Ataxia-telangiectasia (A-T) is an autosomal, recessive disorder that progressively affects multiple organs. A-T is caused by mutations in the Atm gene (ataxia-telangiectasia mutated gene), ... -
Role of glycogen synthase kinase 3 (GSK-3) and its substrate proteins in the development of cardiomyopathy associated with obesity and insulin resistance
(Stellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: INTRODUCTION: Glycogen synthase kinase-3 (GSK-3) is a serine-threonine protein kinase that was first discovered as a regulator of glycogen synthase thus playing a role in glycogen synthesis (Embi et al. ... -
The role of glycogen synthase kinase-3 (GSK-3) protein in the development of myocardial hypertrophy in a rat model of diet induced obesity and insulin resistance
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Introduction: The worldwide escalation in the incidence of obesity and its strong association with insulin resistance, type 2 diabetes and the cardiovascular complications that accompany these disease ... -
The role of mitophagy in damage incurred by ischaemia/reperfusion
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Background and aims: Mitophagy is a specialised process of autophagy whereby dysfunctional mitochondria are removed. Mitophagy has been increasingly recognised as an essential process to sustain a healthy ... -
The role of p38 MAPK activation in preconditioning mediated protection against ischaemia/reperfusion injury
(Stellenbosch : Stellenbosch University, 2002-12)ENGLISH ABSTRACT: The ultimate consequence of the interruption of blood flow to the myocardium is necrosis. In view of the prevalence of coronary artery disease in the general population, and the deleterious effects of ... -
The role of Phosphodiesterase 4 in insulin- and phytocannabinoids-induced cardio-protection, and B-adrenergic cardiac damage.
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: Introduction: Cardiovascular disease (CVD) is one of the main non-communicable diseases globally contributing to deaths each year. Ischemic heart disease leading to myocardial infarction (or heart attack ... -
The role of protein phosphatases in myocardial ischaemia and reperfusion
(Stellenbosch : Stellenbosch University, 2008-03)ENGLISH ABSTRACT: Protein kinases and phosphatases play important roles in the phosphorylation state of intracellular proteins under both physiologic and pathophysiologic conditions. Compared to the large number of studies ... -
The role of the beta3-adrenergic receptor (β3-AR) in cardioprotection
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: It is well-established that transient activation of the β-adrenergic signalling pathway with ligands such as isoproterenol, formoterol and dobutamine, elicits cardioprotection against subsequent long ... -
Short abstinence: Impact on the seminal plasma proteome and accessory sex gland secretions
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Various studies have sought to determine the typical versus optimal abstinence period after which semen samples should be collected, and many have been found to be contradictory. Several factors influence ... -
The Significance of Mitophagy in Myocardial Ischaemia/ Reperfusion: the effect of melatonin
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Myocardial ischaemia and concomitant cell damage are caused by a reduction in the blood supply to the heart. To date, the most effective strategy to salvage the myocardium is timely reperfusion which is ... -
Stem cell impairment associated with type 2 diabetes mellitus : investigating the effects of obesity-associated inflammation on mesenchymal stem cell function
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT : Background: South Africa has the highest prevalence of obesity in sub-Saharan Africa, particularly in Black women. This population is thus at a higher risk of developing obesity-associated type 2 diabetes ... -
A study of the early changes in hearts from diet-induced obese rats that may lead to cardiac dysfunction
(Stellenbosch : University of StellenboschStellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: INTRODUCTION: Obesity and its associated complications such as diabetes and cardiovascular disease are escalating worldwide. Cardiovascular mortality and the occurrence of heart failure following a ... -
The treatment effect of Rooibos on vascular function and signalling pathways of aortas from diet induced obese rats.
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Introduction: Obesity is becoming a worldwide health problem and is a well-documented independent risk factor for the development of endothelial dysfunction (decreased nitric oxide (NO) bioavailability) ... -
Utilization of antigen-specific host responses in the evaluation of Mycobacterium tuberculosis infection, development of disease and treatment effect
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Setting This study was conducted in the Tygerberg district, Cape Town, in the Western Cape, South Africa Background The evaluation of early tuberculosis (TB) treatment response is based on month 2 ...
