Browsing Masters Degrees (Medical Physiology) by Title
Now showing items 25-44 of 70
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Endothelial dysfunction in cardiac microvascular endothelial cells : an investigation into cellular mechanisms and putative role of oleanolic acid in reversing endothelial dysfunction
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Introduction: The discovery of the endothelium as a regulator of vascular tone, and the subsequent discovery of nitric oxide (NO) as the major endothelium-derived relaxing factor (EDRF), has opened up ... -
Establishment and validation of a terminally differentiated adult rat ventricular cardiomyocyte model
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Various experimental models are used in cardiovascular research which includes the whole animal model, whole heart model and heart cell model, with each one having its advantages and disadvantages. Although ... -
Gender selection: separation techniques for X- and Y-chromosome bearing human spermatozoa
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Preconceptual sex selection is an ethically justifiable process whereby X- and Y-chromosome bearing spermatozoa are isolated prior to fertilization of the oocyte in order to generate either a male or a ... -
Genetic markers in the differential diagnosis in a family setting of episodic loss of consciousness
(Stellenbosch : Stellenbosch University, 2000-03)ENGLISH ABSTRACT: Please see fulltext for abstract -
Identifying appropriate attachment factors for isolated adult rat cardiomyocyte culture and experimentation
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Introduction: Primary culture of isolated adult rat cardiomyocytes (ARCMs) is an important model for cardiovascular research, but successful maintenance of these cells in culture for their use in experiments ... -
The impact of activation of the renin-angiotensin system in the development of insulin resistance in experimental models of obesity
(Stellenbosch : University of Stellenbosch, 2009-03)Insulin stimulates the production of nitric oxide (NO) in endothelial cells and cardiac myocytes by a signalling pathway that involves the insulin receptor substrate (IRS)-1, phosphatidylinositol-3-kinase and protein ... -
The impact of oocyte meiotic spindle and automated zona pellucida score and sperm chromatin packaging on fertilization and pregnancy for assisted reproduction techniques
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Non-invasive selection of developmentally competent human oocytes may provide information on the true fertilization potential of the spermatozoon in the absence of oocyte limitations. The objective was ... -
In vitro assessment of aspalathin-enriched Rooibos (Aspalathus linearis) extract treatment in statin-induced hepatotoxicity
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: Rooibos (Aspalathus linearis) has been shown to have various health benefits including antidiabetic, lipid-lowering, and hepatoprotective properties. Although anecdotally Rooibos consumption is regarded ... -
Investigating the ameliorative potential of Aspalathus linearis and Cyclopia intermedia against lipid accumulation, lipolysis, oxidative stress and inflammation
(Stellenbosch : Stellenbosch University, 2020-03)Background Despite the availability of several treatment regimens, obesity continues to be one of the greatest health challenges of the 21st century. In recent years, plant polyphenols have attracted increasing attention ... -
Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity : an in vivo and ex vivo approach
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: An interaction exists between cardiovascular risk factors (e.g. obesity) and antiretroviral treatment (ART) in the pathogenesis of cardiovascular disease. While ART reverses HIV- related ... -
Investigating the effect of simulated Ischemia on phosphatases : comparing a cardiomyocytes (H9c2) cell line with a breast cancer (MDA-MB 231) cell line
(Stellenbosch : Stellenbosch University, 2020-03)Background: Reversible phosphorylation is responsible for an estimated 30% of protein regulation. Protein phosphorylation is catalysed by protein kinases and dephosphorylation by protein phosphatases. Ischemia, which is ... -
Investigating the effects of first line and second line antiretroviral drugs on HIV exposed endothelial function - A clinical study, supported by a mechanistic in-vitro approach
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Background: There is an interaction between HIV, antiretroviral treatment (ART) and endothelial dysfunction; furthermore, HIV-infected individuals (± ART) show an increased incidence of cardiovascular ... -
Investigating the effects of nicotine on the male reproductive system
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Much has been documented about the detrimental effects of adverse lifestyle factor exposure on the body. Exposure to factors, such as cigarette smoke, have proved to not only be a burden on global health ... -
Investigating the modulating effects of Afriplex GRT Extract on vascular function and antioxidant status in obese Wistar rat
(Stellenbosch : Stellenbosch University, 2018-03)Introduction Obesity is associated with the development of metabolic syndrome, a conglomerate of cardiometabolic risk factors, which synergistically result in cardiovascular diseases (CVDs), the major leading cause of ... -
Investigating the Modulating effects of Fermented Rooibos (Aspalathus linearis) and Fermented Honeybush (Cyclopia intermedia) on aortic endothelial function and antioxidant status in Streptozotocin (STZ) – induced diabetic Wistar rats
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Introduction: Diabetes mellitus is a metabolic disorder that causes chronic hyperglycaemia due to insulin resistance and deficiency. The implications that chronic hyperglycaemia has on vascular function ... -
Investigating the onset of insulin resistance and non-alcoholic fatty liver disease in obesity-induced cardiac dysfunction
(Stellenbosch : Stellenbosch University, 2019-04)Introduction: The global obesity epidemic has been associated with various metabolic disorders, including insulin resistance and non-alcoholic fatty liver disease (NAFLD). Insulin resistance is thought be a hallmark of ... -
An investigation into the effects of aspalathin on myocardial glucose transport using cardiomyocytes from control and obesity-induced insulin resistant rats, and terminally differentiated H9C2 cells
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: Rooibos is an indigenous South African plant ingested as herbal tea and well-known for its strong anti-oxidant effects. Rooibos has shown to have cardioprotective properties in vitro and ... -
An investigation of the importance of the ATM protein in the endothelium and its role in the signalling pathways of NO production
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Ataxia telangiectasia (AT) is a well-characterized neurodegenerative disease resulting from a genetic defect in the Atm gene causing an absence or very low expression of the ATM protein. As AT patients ... -
Measurement of free radicals and their effects on human spermatozoa
(Stellenbosch : University of Stellenbosch, 2006-03)In this study, we presented data on the role of free radicals in human spermatozoa, particularly in the context of centrifugation and the potential development of defective sperm function. In order to achieve this, methods ... -
Nitric oxide and the endothelium : characterisation of in vitro nitric oxide detection techniques and an ex vivo method of measuring endothelial function
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Introduction: Nitric oxide (NO) is an important chemical messenger in the cardiovascular system. Despite considerable progress in this field, there remains an on-going need for affordable and user-friendly ...
