Browsing Masters Degrees (Medical Physiology) by Title
Now showing items 11-30 of 70
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The effect of 5'-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and 5'-aminoimidazole-4-carboxamide-ribonucleoside-phosphate (ZMP) on myocardial glucose uptake
(Stellenbosch : Stellenbosch University, 2005-03)ENGLISH ABSTRACT: Introduction: Exercise increases skeletal muscle glucose uptake via AMP-activated protein kinase (AMPK) activation and GLUT4 translocation from cytosol to cell membrane. It also promotes glucose ... -
Effect of Aspalathus linearis supplementation, during anti-retroviral treatment, on the heart and aortas of male Wistar rats and the effects of drinking rooibos on the cardiovascular profile of patients on ART.
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Introduction Improved survival rates in the human immunodeficiency virus (HIV) population, due to the use of antiretroviral therapy (ART), are associated with increased risk for cardiovascular disease ... -
The effect of chronic ingestion of afriplex grt™ on myocardial insulin resistance and mitochondrial function – a preclinical study.
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Obesity is an excessive fat accumulation in the body, known to be a significant precursor to insulin resistance and type 2 diabetes. Complications associated with obesity can contribute to the development of ... -
The effect of CPT-1 inhibition on myocardial function and resistance to ischemia/reperfusion injury in a rodent model of the metabolic syndrome
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Background: Obesity is associated with dyslipidemia, insulin resistance and glucose intolerance and together these components characterise the metabolic syndrome (Dandona et al. 2005). In the state of ... -
The effect of hypoxia on nitric oxide and endothelial nitric oxide synthase in the whole heart and isolated cardiac cells: the role of the PI3–K / PKB pathway as a possible mediator.
(Stellenbosch : University of Stellenbosch, 2009-03)In the heart, endothelial nitric oxide synthase (eNOS) is regarded as the most important constitutively expressed enzymatic source of nitric oxide (NO), a major cardiac signalling molecule. On the whole, NO is regarded ... -
The effect of hypoxia on protein phosphatase 2A (PP2A) in MDA-MB-231 cells, and, a pilot study to establish a primary breast cancer cell model from Fine Needle Aspirations.
(Stellenbosch : Stellenbosch University, 2018-03)Background: Cancerous tumours are characterised by areas of insufficient blood supply, with resulting hypoxia and nutrient deprivation. The mechanisms by which cancer cells adapt to these conditions are of interest due ... -
The effect of lipid modifying drugs on male reproductive parameters
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: The risk of cardiovascular disease (CVD) is prevalent and on the increase globally. Lipid-lowering drugs, have been found to reduce CVD. They act by either reducing LDL or increasing HDL. Thus reducing ... -
Effect of melatonin on myocardial susceptibility to ischaemia and reperfusion damage in a rat model of high-fat diet-induced obesity
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: Obesity has reached epidemic proportions worldwide and is currently a serious health problem. It is associated with metabolic abnormalities, oxidative stress, hypertension, insulin resistance and an ... -
The effects of a watery extract of Agathosma on the development of hypertension
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Introduction: Obesity is a major risk factor for non-communicable diseases (NCD), a collective term given to type 2 diabetes (T2D), hypertension (HTN) and cardiovascular disease (CVD). Globally, NCDs are ... -
The effects of chronic melatonin treatment on myocardial function and ischaemia and reperfusion injury in a rat model of diet-induced obesity
(Stellenbosch : Stellenbosch University, 2010-03)ENGLISH ABSTRACT: Obesity is a major risk factor for ischaemic heart disease. Obesity-induced metabolic abnormalities have been associated with increased oxidative stress which may play an important role in the increased ... -
The Effects of HIV-1-proteins and Antiretroviral Therapy on Aortic Endothelial Cells (AECs) – A Mechanistic in vitro Approach
(Stellenbosch : Stellenbosch University, 2019-04)Introduction: Endothelial dysfunction is an early precursor of cardiovascular disease characterized by decreased nitric oxide (NO) levels following the development of oxidative stress. Oxidative stress has been shown to ... -
The effects of melatonin supplementation on vascular tissue during first line ART: an in vivo, ex vivo and in vitro study
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Although Antiretroviral therapy (ART) has dramatically reduced HIVassociated morbidity and mortality, non-HIV-related conditions and comorbidities continue to rise in this population. Cardiovascular disease ... -
The effects of physical and psychological stress on the behaviour and neurochemistry of rats
(Stellenbosch : University of Stellenbosch, 2005-12)Stress is considered one of the major factors involved in the pathogenesis of affective disorders, for example, direct and indirect exposure to terrorist attacks or being subjected to subtle victimization. There is a long ... -
The efficacy of Diavite tm (Prosopis glandulosa) as anti-diabetic treatment in rat models of streptozotocin-induced type 1 diabetes and diet-induced-obese insulin resistance
(Stellenbosch : University of Stellenbosch, 2010-03)ENGLISH ABSTRACT: Introduction: Obesity and its associated complications, such as the metabolic syndrome, hypertension and cardiovascular disease, are escalating worldwide. In recognition of this, untested remedies advertised ... -
Endothelial dysfunction in cardiac microvascular endothelial cells : an investigation into cellular mechanisms and putative role of oleanolic acid in reversing endothelial dysfunction
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Introduction: The discovery of the endothelium as a regulator of vascular tone, and the subsequent discovery of nitric oxide (NO) as the major endothelium-derived relaxing factor (EDRF), has opened up ... -
Establishment and validation of a terminally differentiated adult rat ventricular cardiomyocyte model
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Various experimental models are used in cardiovascular research which includes the whole animal model, whole heart model and heart cell model, with each one having its advantages and disadvantages. Although ... -
Gender selection: separation techniques for X- and Y-chromosome bearing human spermatozoa
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Preconceptual sex selection is an ethically justifiable process whereby X- and Y-chromosome bearing spermatozoa are isolated prior to fertilization of the oocyte in order to generate either a male or a ... -
Genetic markers in the differential diagnosis in a family setting of episodic loss of consciousness
(Stellenbosch : Stellenbosch University, 2000-03)ENGLISH ABSTRACT: Please see fulltext for abstract -
Identifying appropriate attachment factors for isolated adult rat cardiomyocyte culture and experimentation
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Introduction: Primary culture of isolated adult rat cardiomyocytes (ARCMs) is an important model for cardiovascular research, but successful maintenance of these cells in culture for their use in experiments ... -
The impact of activation of the renin-angiotensin system in the development of insulin resistance in experimental models of obesity
(Stellenbosch : University of Stellenbosch, 2009-03)Insulin stimulates the production of nitric oxide (NO) in endothelial cells and cardiac myocytes by a signalling pathway that involves the insulin receptor substrate (IRS)-1, phosphatidylinositol-3-kinase and protein ...
