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Preclinical assessment of the immunosuppressive properties of an anti-CD4 monoclonal antibody (MAB) in an allogeneic foetal rat pancreatic transplantation model
(Stellenbosch : Stellenbosch University, 2004-12)
ENGLISH ABSTRACT: Introduction
Despite advances in insulin therapy, the side effects associated with diabetes mellitus still
remain. Pancreas transplantation has benefited diabetics with end-stage renal failure by
reversing ...
A histological and morphometric assessment of endocrine and ductular proliferation in the adult rat pancreas using an occlusive pancreatic duct ligation model
(Stellenbosch : Stellenbosch University, 2000-03)
ENGLISH ABSTRACT: Diabetes Mellitus (DM) is synonymous with "B-cell failure". Ligation of the pancreatic
duct distally to its confluence into the bile duct has been shown to induce endocrine
tissue regeneration from a ...
The effect of an in utero high fat diet on the expression of transcription factors and glucose sensing in the developing rat pancreas
(Stellenbosch : Stellenbosch University, 2005-12)
ENGLISH ABSTRACT: A high fat diet (HFD) reduces beta-cell mass, impairs glucose signalling and is
involved in the development of Type 2 diabetes. Malnutrition during gestation is
hypothesized to irreversibly damage ...
Assessment of health status in a 20th century skeletal collection from the Western Cape
(2019-04)
ENGLISH ABSTRACT: Studies on the health status of skeletal remains give insight into the standard of living and survival pattern of historic populations. Analysis of trauma and pathological conditions in human skeletal ...
A morphological assessment of the health status of a cadaver population at the Faculty of Health Sciences, Stellenbosch University, with special reference to tuberculosis (TB) Lesion distribution
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Tuberculosis (TB) is a chronic pulmonary infection characterized by granulomatous inflammation, caseating necrosis and a propensity to develop fibrosis and cavitations. Pulmonary TB (PTB) lesions may ...
An in vitro study of mesenchyme–islet cell interactions in islet neogenesis: A model for tissue replacement therapy in diabetes mellitus
(Stellenbosch : Stellenbosch University, 2017-12)
ENGLISH ABSTRACT : Shortages of donor islets, immune rejection, and the need for life-long immuno-suppressors remain the clinical challenges of islet transplantation in the treatment of diabetes mellitus. An alternative ...
Cellular mechanisms involved in the recapitulation of endocrine development in the duct ligated pancreas
(Stellenbosch : University of Stellenbosch, 2011-03)
ENGLISH ABSTRACT: Diabetes mellitus is amongst the leading causes of morbidity and mortality in the world, affecting
young, adult and old people. Beta cell replacement therapy for insulin delivery remains the ultimate
remedy ...
Hyperglycaemia and its implication on the Pancreatic islet microvasculature in diabetic rat models
(Stellenbosch : Stellenbosch University, 2020-12)
SUMMARY BACKGROUND: Despite the considerable progress made in the treatment of diabetes mellitus, vascular damage remains the leading cause of patient death. The mechanisms underlying vascular abnormalities in ...