Now showing items 1-4 of 4
Intra- and inter-clade cross-reactivity by HIV-1 gag specific T-cells reveals exclusive and commonly targeted regions : implications for current vaccine trials
(Public Library of Science, 2011-10-12)
ENGLISH ABSTRACT: The genetic diversity of HIV-1 across the globe is a major challenge for developing an HIV vaccine. To facilitate immunogen design, it is important to characterize clusters of commonly targeted T-cell ...
History and origin of the HIV-1 subtype C epidemic in South Africa and the greater southern African region
HIV has spread at an alarming rate in South Africa, making it the country with the highest number of HIV infections. Several studies have investigated the histories of HIV-1 subtype C epidemics but none have done so in ...
Mucus and mucins: do they have a role in the inhibition of the human immunodeficiency virus?
(BioMed Central, 2017-10-06)
Background: Mucins are large O-linked glycosylated proteins which give mucus their gel-forming properties. There are indications that mucus and mucins in saliva, breast milk and in the cervical plug inhibit the human ...
Molecular characterization of HIV-1 subtype C gp-120 regions potentially involved in virus adaptive mechanisms
The role of variable regions of HIV-1 gp120 in immune escape of HIV has been investigated. However, there is scant information on how conserved gp120 regions contribute to virus escaping. Here we have studied how molecular ...