Now showing items 1-10 of 13
Interferon-gamma release assays for the detection of Mycobacterium tuberculosis infection in children with cancer
SETTING: The paediatric oncology unit at Tygerberg Children's Hospital, South Africa. OBJECTIVES: To assess the use of the tuberculin skin test (TST) and two commercial interferon-gamma release assays (IGRAs) for the ...
Fine-needle aspiration biopsy: A fi rst-line diagnostic procedure in paediatric tuberculosis suspects with peripheral lymphadenopathy?
OBJECTIVE: To evaluate the diagnostic yield and time to diagnosis of fi ne-needle aspiration biopsy (FNAB) vs. routine respiratory specimens collected from children with a palpable peripheral lymph node mass and symptoms ...
Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa
Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...
Nosocomial transmission of Mycobacterium tuberculosis in kangaroo mother care units: A risk in tuberculosis-endemic areas
Background and aim: Kangaroo mother care (KMC) has become the standard of care for low-risk preterm babies born in developing countries. However, the potential risk of nosocomial transmission of Mycobacterium tuberculosis ...
Diagnosing mycobacterial lymphadenitis in children using fine needle aspiration biopsy: Cytomorphology, ZN staining and autofluorescence-making more of less
Although the incidence of TB has stabilized or declined in most world regions, it is increasing in Africa, Southeast Asia, and the Eastern Mediterranean, fuelled by the HIV pandemic. More than 4,000 people died daily from ...
Tuberculosis in women and children
[No abstract available]
A critical look at the diagnostic value of culture-confirmation in childhood tuberculosis
Objectives: To describe the clinical presentation, delay in diagnosis and treatment initiation, and outcome of culture-confirmed childhood tuberculosis. Methods: Retrospective study of children < 13 years of age at Tygerberg ...
Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa
Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...
Improvement in mycobacterial yield and reduced time to detection in pediatric samples by use of a nutrient broth growth supplement
There is an urgent need to improve the methods used for the bacteriological diagnosis of childhood mycobacterial disease. This study compared the mycobacterial yields and the times to detection (in days) of mycobacteria ...
Radiographic signs and symptoms in children treated for tuberculosis: Possible implications for symptom-based screening in resource-limited settings
Background: The World Health Organization advises active tracing of children younger than 5 years old in household contact with a sputum smear-positive tuberculosis index case. This study compared radiographic disease ...