Now showing items 21-30 of 461
Phase II trial of ZD0473 as second-line therapy in mesothelioma
A phase II, open-label, non-comparative, multicentre trial of the platinum analogue ZD0473 as second-line therapy for pleural mesothelioma has been completed. The objectives were to evaluate the activity and tolerability ...
Esomeprazole 40 mg administered intravenously has similar safety and efficacy profiles to the oral formulation in patients with erosive esophagitis
Background/Aims: An intravenous formulation of esomeprazole has been developed for use in patients where oral administration is not appropriate. This study evaluated safety after 1 and 4 weeks, and efficacy after 4 weeks' ...
An intrapericardial hernia
[No abstract available]
Pharmacodynamic equivalence of a decapeptyl 3-month SR formulation with the 28-day SR formulation in patients with advanced prostate cancer
Aims: The objective of the study was to assess the pharmacodynamic equivalence of LHRH analogue triptorelin 3-month and 28-day SR formulations. Methods: Patients with documented locally advanced or metastatic prostate ...
An atropine and glycopyrrolate combination reduces mortality in organophosphate poisoning
Anticholinergics are the mainstay of the pharmacological management of organophosphate poisoning (OPP). Atropine has the potential to cause central toxicity which may complicate the management of this life-threatening ...
A study of semen parameters with emphasis on sperm morphology in a fertile population: An attempt to develop clinical thresholds
The aim of the study was to determine the semen parameters of a proven fertile population and to compare these parameters with that of a subfertile group in the same region. Sixty-nine fertile male patients were studied ...
Detection of p53 gene mutations in oral squamous cell carcinomas of a black african population sample
Mutations in the p53 gene have been reported in head and neck carcinomas. We determined the p53 mutation profile in 55 oral squamous cell carcinomas (OSCCs) from a black African population sample. DNA from all the patients ...
Post-traumatic stress disorder among recently diagnosed patients with HIV/AIDS in South Africa
This study examined the prevalence of and factors associated with post-traumatic stress disorder in recently diagnosed HIV/AIDS patients in South Africa. One hundred and forty-nine (44 male, 105 female) recently diagnosed ...
Bowel herniation through the torn diaphragm: II. Intestinal herniation
Five cases of intestinal herniation through the torn diaphragm are presented. Plain radiography, single contrast examination, and ultrasonography show some simple features that either have not been previously published or ...
Efficacy and safety of pantoprazole 20 mg once daily treatment in patients with ulcer-like functional dyspepsia
Objective: To investigate the efficacy of pantoprazole 20 mg once daily (o.d.) in relieving epigastric pain associated with ulcer-like functional dyspepsia. Research design and methods: In this double-blind, placebo-controlled, ...