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Correlation between p53 gene mutation, p53 protein labeling and PCNA expression in oral squamous cell carcinomas
(1998)
Background: The prevalence of oral squamous cell carcinoma (OSCC) among the Black community in South Africa is unacceptably high. The association between p53 protein, and PCNA overexpression and the presence of p53 gene ...
Papulonecrotic tuberculid in children: A report of eight patients
(1996)
Papulonecrotic tuberculid (PNT), a form of cutaneous tuberculosis (TB), is uncommon in children. We identified eight children (six girls and two boys) with PNT. Their ages ranged from 19 to 139 months (median: 47.5 months, ...
Papular urticaria: A histopathologic study of 30 patients
(1997)
Papular urticaria is the result of hypersensitivity (id-reaction) to bites from certain insects such as mosquitoes gnats, fleas, mites, and bedbugs. Papular urticaria is common in childhood and is characterized by symmetrically ...
The origins of hypertrophic cardiomyopathy-causing mutations in two South African subpopulations: A unique profile of both independent and founder events
(1999)
Hypertrophic cardiomyopathy (HCM) is an autosomal dominantly inherited disease of the cardiac sarcomere, caused by numerous mutations in genes encoding protein components of this structure. Mutation carriers are at risk ...
Efficacy and tolerability of pantoprazole 40 mg versus 80 mg in patients with reflux oesophagitis
(1996)
Background: Pantoprazole is a substituted benzimidazole which is a potent inhibitor of gastric acid secretion by its action upon H+,K+-ATPase. Methods: Pantoprazole 40 mg and 80 mg were compared in a randomized double-blind ...
Analysis of spinocerebellar ataxia types 1, 2, 3, and 6, dentatorubral-pallidoluysian atrophy, and Friedreich's ataxia genes in spinocerebellar ataxia patients in the UK
(1997)
Accurate clinical diagnosis of the spino-cerebellar ataxias (SCAs) can be diffcult because of overlap in phenotype with other disorders and variation in clinical manifestations. Six SCA loci have been mapped and four disease ...
Inhibition of G protein in human sperm and its influence on acrosome reaction and zona pellucida binding
(1996)
Objective: To evaluate human sperm acrosomal status, zona pellucida (ZP)-binding capacity, and sperm motion characteristics after treatment with pertussis toxin followed by exposure to increasing concentrations of solubilized ...
Clinical significance of human sperm-zona pellucida binding
(1997)
Objective: To assess the relationship between sperm morphology and motion parameters and sperm-zona pellucida (ZP) binding capacity under hemizona assay (HZA) conditions and to determine the discriminatory power of the HZA ...
Preservation of function by radiotherapy of small primary carcinomas preceded by neck dissection for extensive nodal metastases of the head and neck
(1996)
Background. When patients are initially seen with a small primary tumor and regional metastases, the question arises whether the primary can be managed by definitive radiotherapy while treating the neck with surgery and ...
A novel deletion at codon 441 of the APC gene associated with ophthalmic lesions (CHRPE) in a South African family
(1996)
A novel mutation at codon 441 in exon 10 of the adenomatous polyposis coli (APC) gene was identified in a South African family of mixed ancestry, using a convenient, non-radioactive, heteroduplex-SSCP screening assay. This ...