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Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa

Fenner L.; Brinkhof M.W.G.; Keiser O.; Weigel R.; Cornell M.; Moultrie H.; Prozesky H.; Technau K.; Eley B.; Vaz P.; Pascoe M.; Giddy J.; Van Cutsem G.; Wood R.; Egger M.; Davies M.-A. (2010)

Background: Many HIV-infected children in Southern Africa have been started on antiretroviral therapy (ART), but loss to follow up (LTFU) can be substantial. We analyzed mortality in children retained in care and in all ...

Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid

Cilliers K.; Labadarios D.; Schaaf H.S.; Willemse M.; Maritz J.S.; Werely C.J.; Hussey G.; Donald P.R. (2010)

Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...

Prioritising prevention strategies for patients in antiretroviral treatment programmes in resource-limited settings

Spaar A.; Graber C.; Dabis F.; Coutsoudis A.; Bachmann L.; McIntyre J.; Schechter M.; Prozesky H.W.; Tuboi S.; Dickinson D.; Kumarasamy N.; Pujdades-Rodriquez M.; Sprinz E.; Schilthuis H.J.; Cahn P.; Low N.; Egger M. (2010)

Expanded access to antiretroviral therapy (ART) offers opportunities to strengthen HIV prevention in resource-limited settings. We invited 27 ART programmes from urban settings in Africa, Asia and South America to participate ...

Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007

Cornell M.; Grimsrud A.; Fairall L.; Fox M.P.; Van Cutsem G.; Giddy J.; Wood R.; Prozesky H.; Mohapi L.; Graber C.; Egger M.; Boulle A.; Myer L. (2010)

Objective: Little is known about the temporal impact of the rapid scale-up of large antiretroviral therapy (ART) services on programme outcomes. We describe patient outcomes [mortality, loss-to-follow-up (LTFU) and retention] ...

Evaluation of paradoxical TB-associated IRIS with the use of standardized case definitions for resource-limited settings

Eshun-Wilson I.; Havers F.; Nachega J.B.; Prozesky H.W.; Taljaard J.J.; Zeier M.D.; Cotton M.; Simon G.; Soentjens P. (2010)

Objective: Standardized case definitions have recently been proposed by the International Network for the Study of HIV-associated immune reconstitution inflammatory syndrome (INSHI; [IRIS]) for use in resource-limited ...

Inhibitors and facilitators of willingness to participate (WTP) in an HIV vaccine trial: Construction and initial validation of the Inhibitors and Facilitators of Willingness to Participate Scale (WPS) among women at risk for HIV infection

Fincham D.; Kagee A.; Swartz L. (2010)

A psychometric scale assessing inhibitors and facilitators of willingness to participate (WTP) in an HIV vaccine trial has not yet been developed. This study aimed to construct and derive the exploratory factor structure ...

Positive futures: A qualitative study on the needs of adolescents on antiretroviral therapy in South Africa

Li R.J.; Jaspan H.B.; O'Brien V.; Rabie H.; Cotton M.F.; Nattrass N. (2010)

With the increasing availability of highly active antiretroviral therapy, vertically infected children have a better chance of surviving into adolescence and adulthood. Additionally, sexual transmission of human immunodeficiency ...

Renal manifestations in children co-infected with HIV and disseminated tuberculosis

Nourse P.J.; Cotton M.F.; Bates W.D. (2010)

Many children in Cape Town are co-infected with human immunodeficiency virus (HIV) and tuberculosis (TB). Granulomatous TB interstitial nephritis is a recognized entity. Our objective was to establish if TB plays a role ...