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Evaluating the BED capture enzyme immunoassay to estimate HIV incidence among adults in three countries in sub-Saharan Africa

Kim, A. A.; McDougal, J. S.; Hargrove, J.; Rehle, T.; Pillay-Van Wyk, V.; Puren, A.; Ekra, A.; Borget-Alloue, M. Y.; Adje-Toure, C.; Abdullahi, A. S.; Odawo, L.; Marum, L.; Parekh, B. S. (2010)

Serological assays for estimating HIV-1 incidence are prone to misclassification, limiting the accuracy of the incidence estimate. Adjustment factors have been developed and recommended for estimating assay-based HIV-1 ...

Interferon-gamma release assays for the detection of Mycobacterium tuberculosis infection in children with cancer

Stefan D.C.; Dippenaar A.; Detjen A.K.; Schaaf H.S.; Marais B.J.; Kriel B.; Loebenberg L.; Walzl G.; Hesseling A.C. (2010)

SETTING: The paediatric oncology unit at Tygerberg Children's Hospital, South Africa. OBJECTIVES: To assess the use of the tuberculin skin test (TST) and two commercial interferon-gamma release assays (IGRAs) for the ...

Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa

Fenner L.; Brinkhof M.W.G.; Keiser O.; Weigel R.; Cornell M.; Moultrie H.; Prozesky H.; Technau K.; Eley B.; Vaz P.; Pascoe M.; Giddy J.; Van Cutsem G.; Wood R.; Egger M.; Davies M.-A. (2010)

Background: Many HIV-infected children in Southern Africa have been started on antiretroviral therapy (ART), but loss to follow up (LTFU) can be substantial. We analyzed mortality in children retained in care and in all ...

Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid

Cilliers K.; Labadarios D.; Schaaf H.S.; Willemse M.; Maritz J.S.; Werely C.J.; Hussey G.; Donald P.R. (2010)

Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...

Prioritising prevention strategies for patients in antiretroviral treatment programmes in resource-limited settings

Spaar A.; Graber C.; Dabis F.; Coutsoudis A.; Bachmann L.; McIntyre J.; Schechter M.; Prozesky H.W.; Tuboi S.; Dickinson D.; Kumarasamy N.; Pujdades-Rodriquez M.; Sprinz E.; Schilthuis H.J.; Cahn P.; Low N.; Egger M. (2010)

Expanded access to antiretroviral therapy (ART) offers opportunities to strengthen HIV prevention in resource-limited settings. We invited 27 ART programmes from urban settings in Africa, Asia and South America to participate ...

Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007

Cornell M.; Grimsrud A.; Fairall L.; Fox M.P.; Van Cutsem G.; Giddy J.; Wood R.; Prozesky H.; Mohapi L.; Graber C.; Egger M.; Boulle A.; Myer L. (2010)

Objective: Little is known about the temporal impact of the rapid scale-up of large antiretroviral therapy (ART) services on programme outcomes. We describe patient outcomes [mortality, loss-to-follow-up (LTFU) and retention] ...

Rare case of perplexing ovarian endometriosis

Van Der Merwe J.L.; Siebert I.; Van Wyk A.C. (2010)

Objective: To document a rare case of coexisting endometriosis and mature cystic teratoma in the same ovary. Design: Case report. Setting: Gynecology unit in a tertiary training and teaching hospital in Cape Town, South ...

Evaluation of paradoxical TB-associated IRIS with the use of standardized case definitions for resource-limited settings

Eshun-Wilson I.; Havers F.; Nachega J.B.; Prozesky H.W.; Taljaard J.J.; Zeier M.D.; Cotton M.; Simon G.; Soentjens P. (2010)

Objective: Standardized case definitions have recently been proposed by the International Network for the Study of HIV-associated immune reconstitution inflammatory syndrome (INSHI; [IRIS]) for use in resource-limited ...

Symptoms of depression and anxiety among a sample of South African patients living with HIV

Kagee A.; Martin L. (2010)

Little systematic research has been conducted on the extent of psychiatric disorders among South African patients in general, and among patients living with HIV in particular. The present study reports on a survey conducted ...

Inhibitors and facilitators of willingness to participate (WTP) in an HIV vaccine trial: Construction and initial validation of the Inhibitors and Facilitators of Willingness to Participate Scale (WPS) among women at risk for HIV infection

Fincham D.; Kagee A.; Swartz L. (2010)

A psychometric scale assessing inhibitors and facilitators of willingness to participate (WTP) in an HIV vaccine trial has not yet been developed. This study aimed to construct and derive the exploratory factor structure ...