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Analysis of spinocerebellar ataxia types 1, 2, 3, and 6, dentatorubral-pallidoluysian atrophy, and Friedreich's ataxia genes in spinocerebellar ataxia patients in the UK
Accurate clinical diagnosis of the spino-cerebellar ataxias (SCAs) can be diffcult because of overlap in phenotype with other disorders and variation in clinical manifestations. Six SCA loci have been mapped and four disease ...
Clinical significance of human sperm-zona pellucida binding
Objective: To assess the relationship between sperm morphology and motion parameters and sperm-zona pellucida (ZP) binding capacity under hemizona assay (HZA) conditions and to determine the discriminatory power of the HZA ...
DNA haplotypes of the complement C6 and C7 genes associated with deficiencies of the seventh component; And a new DNA polymorphism in C7 exon 13
Eight common DNA polymorphisms have been described for the linked C6 and C7 genes. We now describe a ninth polymorphism in C7 exon 13 which is located in a tight cluster with two previously reported markers. We have used ...
Internal urethrotomy versus dilation as treatment for male urethral strictures: A prospective, randomized comparison
Purpose: We compared the efficacy of dilation versus internal urethrotomy as initial outpatient treatment for male urethral stricture disease. Materials and Methods: A total of 210 men with proved urethral strictures was ...
The influence of the angiotensin I converting enzyme genotype in familial hypertrophic cardiomyopathy varies with the disease gene mutation
Familial hypertrophic cardiomyopathy is an autosomal dominant genetically heterogeneous disease characterized by a partial penetrance and variable expressivity. Previous studies showed that the extent of hypertrophy is ...
rhuIL-2 adjunctive therapy in multidrug resistant tuberculosis: A comparison of two treatment regimens and placebo
Setting: Low-dose recombinant human interleukin 2 (rhuIL-2) adjunctive immunotherapy in multidrug resistant tuberculosis (MDR-TB) patients. Objective: Evaluation of the effects of daily versus pulse-administered rhuIL-2 ...