Now showing items 1-8 of 8
Enhanced therapeutic efficacy in cancer patients by short-term fasting : the autophagy connection
(Frontiers Media, 2016)
Preclinical studies suggest that fasting prior to chemotherapy may be an effective strategy to protect patients against the adverse effects of chemo-toxicity. Fasting may also sensitize cancer cells to chemotherapy. It is ...
Commentary on : "A common origin for immunity and digestion"
(Frontiers Media, 2015-05)
Was the evolutionary road towards adaptive immunity paved with endothelium?
(BioMed Central, 2015)
Background: The characterization of a completely novel adaptive immune system (AIS) in jawless vertebrates (hagfish and lampreys) presents an excellent opportunity for exploring similarities and differences in design principles. ...
Domesticating cancer : an evolutionary strategy in the war on cancer
(Frontiers Media, 2017)
Since cancer shares the same molecular machinery as the host, most therapeutic interventions that aim to target cancer would inadvertently also adversely affect the host. In addition, cancer continuously evolves, streamlining ...
Hyperglycaemia in critically ill patients : the immune system’s sweet tooth
(BioMed Central, 2017)
There is an ongoing debate regarding the efficacy of glycaemic control in critically ill patients. Here we briefly highlight the key function of elevated glucose in critically ill patients, namely, to enable elevation of ...
The role of bile acids in nutritional support
(BioMed Central, 2018-09-30)
Abstract: Nutritional support continues to receive much attention as a possible intervention to prevent loss of lean tissue mass, promote recovery and re-establish proper immune function in critical care patients. Yet there ...
Sickness-associated anorexia : mother nature’s idea of immunonutrition?
(Hindawi Publishing Corporation, 2016)
During an infection, expansion of immune cells, assembly of antibodies, and the induction of a febrile response collectively place continual metabolic strain on the host. These considerations also provide a rationale for ...
An evaluation of the hepatic proteomic signature in identifying cancer tolerance and resistance mechanisms in a mouse allograft system
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH ABSTRACT: Background The unfavourable therapeutic index of most treatment modalities has greatly impeded progress in the development of effective cancer therapy. Therefore a need exists for treatment modalities ...