Now showing items 1-5 of 5
Domesticating cancer : an evolutionary strategy in the war on cancer
(Frontiers Media, 2017)
Since cancer shares the same molecular machinery as the host, most therapeutic interventions that aim to target cancer would inadvertently also adversely affect the host. In addition, cancer continuously evolves, streamlining ...
Metabolic syndrome and body shape predict differences in health parameters in farm working women
(BioMed Central, 2018-04-04)
Background: Sufficient evidence associate body shape to detrimental lifestyle diseases including the metabolic syndrome (MetS). The prevalence of the MetS, as well as effects of the MetS and body shape on body ...
Sickness-associated anorexia : mother nature’s idea of immunonutrition?
(Hindawi Publishing Corporation, 2016)
During an infection, expansion of immune cells, assembly of antibodies, and the induction of a febrile response collectively place continual metabolic strain on the host. These considerations also provide a rationale for ...
Chemoresistance : intricate interplay between breast tumor cells and adipocytes in the tumor microenvironment
(Frontiers Media, 2018-12-11)
Excess adipose tissue is a hallmark of an overweight and/or obese state as well as a primary risk factor for breast cancer development and progression. In an overweight/obese state adipose tissue becomes dysfunctional due ...
Decreased efficacy of doxorubicin corresponds with modifications in lipid metabolism markers and fatty acid profiles in breast tumors from obese vs. lean mice
(Frontiers Media, 2018-03-17)
Breast cancer cells modulate lipid and fatty acid metabolism to sustain proliferation. The role of adipocytes in cancer treatment efficacy remains, however, to be fully elucidated. We investigated whether diet-induced ...