• Design and synthesis of novel antimalarial agents 

      De Jager, Josephus Jacobus (Stellenbosh : Stellenbosh University, 2014-12)
      ENGLISH ABSTRACT: Malaria is a pestilent disease associated with massive socioeconomic burden of sub-Saharan Africa. This disease is caused by a blood infection of the single cellular parasite of the Plasmodium genus. Two ...
    • The rational design and synthesis of novel HIV non-nucleoside reverse transcriptase inhibitors 

      Muller, Ronel (Stellenbosch : Stellenbosch University, 2013-12)
      ENGLISH ABSTRACT: With a cure for HIV and AIDS still absent, non-nucleoside reverse transcriptase inhibitors (NNRTIs) play a major role in the current antiretroviral treatments used, which have shown to improve and prolong ...
    • The synthesis of novel kinase inhibitors using click chemistry 

      Hodson, Luke (Stellenbosch : Stellenbosch University, 2014-04)
      ENGLISH ABSTRACT: Cancer is the leading cause of death on the planet, killing an estimated 8.2 million people in the year of 2012.The disease is associated with two families of genes, namely oncogenes and tumour suppressor ...
    • Synthesis of novel Tetrahydroisoquinoline-related estrogen receptor modulators 

      Mabank, Tanya (Stellenbosch : Stellenbosch University, 2019-03)
      ENGLISH ABSTRACT: The tetrahydroisoquinoline (THIQ) core has displayed a rich history as a biologically active natural product and is an interesting scaffold to use in drug discovery. Its structural skeleton is present ...
    • Towards the synthesis of makaluvamine-analogues 

      Botes, Marthinus Gerhardus (Stellenbosch : Stellenbosch University, 2015-04)
      ENGLISH ABSTRACT: Cancer is one of the leading causes of death in developed countries and rising fast as a cause of death in developing countries. The increase of cancer prevalence in developing countries can be attributed ...