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Design and synthesis of dual-active heterocyclic yybrid inhibitors for β-Hematin and plasmodium falciparum N-Myristoyltransferase
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: The current project focused on the design and synthesis of a novel antiplasmodial dual-active conjugate hybrid compound based on an indole scaffold and known antiplasmodial quinolines. The two scaffolds ... -
Design, synthesis and biological activity studies of 1-aryl-3-(4-methoxybenzyl)ureas as proposed irreversible GSK-3 inhibitors in Alzheimer’s disease therapeutic development
(Stellenbosch : Stellenbosch University, 2019-03)ENGLISH ABSTRACT: Alzheimer’s disease (AD) is a progressive neurodegenerative disease, characterised by memory loss and cognitive decline. No cure has been found for the disease yet, therefore the development of disease-modifying ... -
Towards the synthesis of makaluvamine-analogues
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Cancer is one of the leading causes of death in developed countries and rising fast as a cause of death in developing countries. The increase of cancer prevalence in developing countries can be attributed ...
