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Alcohol-induced psychotic disorder: brain perfusion and psychopathology--before and after anti-psychotic treatment.

dc.contributor.authorJordaan G.P.
dc.contributor.authorWarwick, James M.en_ZA
dc.contributor.authorNel D.G.
dc.contributor.authorHewlett R.
dc.contributor.authorEmsley R.
dc.date.accessioned2012-06-13T08:43:06Z
dc.date.available2012-06-13T08:43:06Z
dc.date.issued2012
dc.identifier.citationMetabolic brain disease
dc.identifier.citation27
dc.identifier.citation1
dc.identifier.citation67
dc.identifier.citation77
dc.identifier.issn15737365
dc.identifier.otherdoi:10.1007/s11011-011-9273-7
dc.identifier.urihttp://hdl.handle.net/10019.1/21411
dc.description.abstractAlcohol-induced psychotic disorder (AIPD) also known as alcohol hallucinosis is a rare complication of alcohol abuse. The pathogenesis and treatment of AIPD are still unclear. Few prospective treatment studies are available but case reports generally suggest that anti-psychotic treatment is effective. Brain imaging changes in relation to treatment response have also not been studied except for case reports. The aim of this study was to investigate the effect of anti-psychotic treatment on psychopathology and regional cerebral blood flow (rCBF) in patients with AIPD before and after 6 weeks of treatment. Nineteen patients with AIPD were assessed by the Positive and Negative Syndrome Scale (PANSS) and single photon emission computed tomography (SPECT) before and after 6-weeks of open-label treatment with a fixed dose of haloperidol (5 mg/day). Highly significant improvements were noted on the positive, general and total scores of the PANSS. Post-treatment increased rCBF to the left caudate and left frontal lobe was noted. Changes in frontal, temporal, parietal, occipital, thalamic and cerebellar rCBF showed significant negative correlations with the degree of symptom improvement, suggesting dysfunction of these areas in AIPD. Psychopathological and rCBF findings suggest reversible generalised cerebral dysfunction in AIPD.
dc.subjecthaloperidol
dc.subjectneuroleptic agent
dc.subjectadult
dc.subjectalcohol psychosis
dc.subjectalcoholism
dc.subjectarticle
dc.subjectbrain circulation
dc.subjectbrain cortex
dc.subjectdrug effect
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectmental disease
dc.subjectmethodology
dc.subjectneuroimaging
dc.subjectneuropsychological test
dc.subjectperfusion
dc.subjectpsychological aspect
dc.subjectscintiscanning
dc.subjectsingle photon emission computer tomography
dc.subjectvascularization
dc.subjectAdult
dc.subjectAlcoholism
dc.subjectAntipsychotic Agents
dc.subjectCerebral Cortex
dc.subjectCerebrovascular Circulation
dc.subjectFemale
dc.subjectHaloperidol
dc.subjectHumans
dc.subjectMale
dc.subjectNeuroimaging
dc.subjectNeuropsychological Tests
dc.subjectPerfusion
dc.subjectPsychopathology
dc.subjectPsychoses, Alcoholic
dc.subjectTomography, Emission-Computed, Single-Photon
dc.titleAlcohol-induced psychotic disorder: brain perfusion and psychopathology--before and after anti-psychotic treatment.
dc.typeArticle


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