Inositol phosphoglycan P-type in infants of preeclamptic mothers
Date
2012
Authors
Scioscia M.
Robillard P.-Y.
Hall D.R.
Rademacher L.H.
Williams P.J.
Rademacher T.W.
Journal Title
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Abstract
Background. Inositol phosphoglycan P-type (P-IPG) has consistently found to be elevated during active preeclampsia, although the biosynthetic source has to be identified yet. This multicenter prospective cross-sectional case-control study evaluated the fetus/newborn as the source of P-IPG. Methods. A urine specimen was collected longitudinally for three consecutive days after delivery from 90 newborns and their mothers, and ordered according to clinical diagnosis of preeclampsia, gestational hypertension, or healthy pregnancy. Results. The urinary excretion of P-IPG on day 0 was higher in the mothers in all groups (p<0.05) with higher levels in preeclamptic women (p<0.01) in the mothers compared to their newborns in the preeclamptic group (p<0.01). The difference persisted at least two days post partum. Conclusion. Findings of this study confirm the specificity of the increase in urinary excretion of P-IPG in preeclamptic mothers at day of birth compared to healthy pregnancy and GH, but does not extend to their newborns. © 2012 Informa UK, Ltd.
Description
Keywords
inositol derivative, inositol phosphoglycan P type, unclassified drug, article, blood pressure measurement, carbohydrate synthesis, case control study, clinical article, cross-sectional study, disease association, female, fetus, human, maternal hypertension, newborn, preeclampsia, pregnancy outcome, priority journal, prospective study, puerperium, sensitivity and specificity, upregulation, urinalysis, urinary excretion, urine level
Citation
Journal of Maternal-Fetal and Neonatal Medicine
25
2
193
195
25
2
193
195