Repetitive stressors at various lifetime periods differentially affect the HPA axis, neuronal neurotrophic factors and behavioural responses

Faure, Jacqueline J (2006-03)

Thesis (MSc (Physiological Sciences))--University of Stellenbosch, 2006.


Early adverse life events appear to increase the susceptibility of developing psychiatric disorders later in life. The molecular mechanisms involved in the development of pathological behaviour remain unclear. Dysregulation of the hypothalamic-pituitary-adrenal axis and alterations in neurotrophic factors have been implicated.

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