Now showing items 1-10 of 24
Hepatitis B virus infection in HIV-exposed infants in the Western Cape, South Africa
Hepatitis B virus infection (HBV) is a significant public health problem in sub-Saharan Africa. Universal infant vaccination with the hepatitis B (HB) vaccine has been implemented within the South African Expanded Programme ...
Novel arenavirus isolates from Namaqua rock mice, Namibia, Southern Africa
(Centers for Disease Control and Prevention (CDC), 2015-07)
Arenaviruses are feared as agents that cause viral hemorrhagic fevers. We report the identification, isolation, and genetic characterization of 2 novel arenaviruses from Namaqua rock mice in Namibia. These findings extend ...
Rooting the phylogenetic tree of Middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat
(American Society for Microbiology, 2014-10)
The emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes lethal respiratory infections mainly on the Arabian Peninsula. The evolutionary origins of MERS-CoV are unknown. We determined the full genome ...
The HIV/HBV co-infected patient : time for proactive management
(Health and Medical Publishing Group, 2015-02)
Hepatitis B virus (HBV) infection affects around 240 million people worldwide, with the highest prevalence of disease in Africa and Asia. Hepatocellular carcinoma (HCC) is the second most common cancer in men in Africa, ...
38 years after its discovery, Ebola virus spins out of control
(South African Centre for Epidemiological Modelling and Analysis (SACEMA), 2014-09)
The evolutionary origin of Ebolaviruses is not very clear. The simple notion that these viruses have been circulating for many millennia in wildlife in tropical parts of Africa, occasionally spilling over into human ...
Pooled HIV-1 Viral Load Testing Using Dried Blood Spots to Reduce the Cost of Monitoring Antiretroviral Treatment in a Resource-Limited Setting
(Lippincott Williams & Wilkins Open Access, 2013-10)
Rollout of routine HIV-1 viral load monitoring is hampered by high costs and logistical difficulties associated with sample collection and transport. New strategies are needed to overcome these constraints. Dried blood ...
Pandemic flu (H1N1) 2009 and pregnancy
(Health and Medical Publishing Group (HMPG), 2010-04)
Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa
(Centers for Disease Control and Prevention (CDC), 2013-10)
We now report the identification of a South Africa bat derived CoV that has an even closer phylogenetic relationship with MERS-CoV.
Trends in genotypic HIV-1 antiretroviral resistance between 2006 and 2012 in South African patients receiving first- and second-line antiretroviral treatment regimens
(Public Library of Science -- PLoS, 2013-06)
Objectives: South Africa’s national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. ...
Effects of prednisolone on disease progression in antiretroviral-untreated HIV infection : a 2-year randomized, double-blind placebo-controlled clinical trial
(Public Library of Science, 2016)
Background: HIV-disease progression correlates with immune activation. Here we investigated whether corticosteroid treatment can attenuate HIV disease progression in antiretroviral-untreated patients. Methods: Double-blind, ...