Now showing items 1-6 of 6
Functional analysis of novel SLC11A1 (NRAMP1) promoter variants in susceptibility to HIV-1
(BMJ Publishing Group, 2004-04)
The divalent cation transporter is the natural resistance associated macrophage protein 1 (formerly NRAMP1 and now named SLC11A1) for solute carrier 11A1 (OMIM accession number 600266). The gene that codes for this transporter ...
Blood dendritic cells in chronically HIV-1 infected individuals in South Africa: Phenotype, function and immune modulation
(Stellenbosch : Stellenbosch University, 2016-12)
ENGLISH ABSTRACT :HIV-1 infection detrimentally affects CD4 T lymphocytes as well as the blood plasmacytoid (pDC) and myeloid dendritic cell (mDC) compartment. DCs act as innate sensors and as initiators and directors ...
Development of selective real-time PCR (SPCR) asays for the detection of K103N resistance mutation in minor HIV-1 populations
(Stellenbosch : Stellenbosch University, 2011-12)
ENGLISH ABSTRACT: Background: The conventional sequence analysis is the most common method used for the detection of drug-resistant mutants. Due to its sensitivity limitations, it is unable to detect these mutants when ...
HIV-1C dynamics and evolutionary trends in Botswana
(Stellenbosch : Stellenbosch University, 2016-12-09)
ENGLISH ABSTRACT : Introduction: HIV incidence estimates are critical for monitoring HIV transmission dynamics, and for design and evaluation of the impact of interventions. Biomarkers and assays for cross-sectional surveillance ...
Molecular characterization of non-subtype C and recombinant HIV-1 viruses from Cape Town, South Africa
(Stellenbosch : University of Stellenbosch, 2009-03)
ENGLISH ABSTRACT: HIV-1 was first diagnosed within South Africa in 1982. In the 1980’s homosexual transmission dominated the HIV-1 epidemic within the country. In the late 1980’s the second HIV-1 epidemic was recognized ...
Characterisation of new full-length HIV-1 subtype D viruses from South Africa
ENGLISH ABSTRACT: The first episode of HIV-1 in South Africa was documented in 1982. Homosexual transmission of the virus was the predominate mode of transmission in an epidemic of mainly HIV-1 subtype Band D infections. ...