Now showing items 1-6 of 6
Moderate levels of pre-treatment HIV-1 antiretroviral drug resistance detected in the first South African national survey
(Public Library of Science, 2016)
Background: In order to assess the level of transmitted and/or pre-treatment antiretroviral drug resistance to HIV-1, the World Health Organization (WHO) recommends that regular surveys are conducted. This study’s objective ...
HIV evolution and diversity in ART-treated patients
(BioMed Central, 2018-01-30)
Characterizing HIV genetic diversity and evolution during antiretroviral therapy (ART) provides insights into the mechanisms that maintain the viral reservoir during ART. This review describes common methods used to obtain ...
Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa
(Nature Publishing Group, 2018)
ENGLISH ABSTRACT: HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to characterize the HIV-1 IN gene in a South African context and identify resistance-associated mutations ...
HBV and HIV viral load but not microbial translocation or immune activation are associated with liver fibrosis among patients in South Africa
(BioMed Central, 2018-05-08)
Background: Co-infection with HIV negatively impacts the progression of chronic hepatitis B virus (HBV) infection, including causing rapid progression to liver fibrosis. Sub-Saharan Africa represents arguably the most ...
Hepatitis B virus mother-to-child transmission in Namibia: transmission dynamics and possibilities for elimination
(Stellenbosch : Stellenbosch University, 2019-12)
ENGLISH ABSTRACT: Introduction: Hepatitis B virus (HBV) remains endemic in sub-Saharan Africa (SSA). While the roll-out of pediatric HBV immunization from six weeks of age has had an impact on horizontal transmission of ...
Investigation of the HIV diversity in the Cape Winelands, Overberg and West Coast districts of the Western Cape Province of South Africa
(Stellenbosch : Stellenbosch University, 2017-03)
ENGLISH SUMMARY: The Western Cape Province of South Africa has a well-established program that monitors active combination antiretroviral therapy (cART) against HIV-1. The HIV-1 prevalence rate in the Province has increased ...