Browsing Medical Virology by Title
Now showing items 1-20 of 128
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38 years after its discovery, Ebola virus spins out of control
(South African Centre for Epidemiological Modelling and Analysis (SACEMA), 2014-09)The evolutionary origin of Ebolaviruses is not very clear. The simple notion that these viruses have been circulating for many millennia in wildlife in tropical parts of Africa, occasionally spilling over into human ... -
Aberrant in vitro HLA-DR expression in patients with chronic fatigue
(Health and Medical Publishing Group (HMPG), 1990-08)To the Editor: The chronic fatigue syndrome (CFS) is a clinical entity characterised by chronic fluctuating fatigue associated-with a multitude of related symptoms, which may vary between patients. It is of unknown ... -
Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa
(Nature Publishing Group, 2018)ENGLISH ABSTRACT: HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to characterize the HIV-1 IN gene in a South African context and identify resistance-associated mutations ... -
Analysis of viral diversity in relation to the recency of HIV-1C infection in Botswana
(Public Library of Science, 2016)Background: Cross-sectional, biomarker methods to determine HIV infection recency present a promising and cost-effective alternative to the repeated testing of uninfected individuals. We evaluate a viral-based assay ... -
Anti-HIV-1 activity of salivary MUC5B and MUC7 mucins from HIV patients with different CD4 counts
(BioMed Central, 2010-10)Background: We have previously shown that MUC5B and MUC7 mucins from saliva of HIV negative individuals inhibit HIV-1 activity by 100% in an in vitro assay. The purpose of this subsequent study was to investigate whether ... -
Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life
(American Society for Microbiology, 2013-01)HIV-exposed but uninfected (HEU) infants born to HIV-infected mothers from areas in the world with a high burden of infectious disease suffer higher infectious morbidity and mortality than their HIV unexposed uninfected ... -
The apoptotic potential of different HIV-1 subtype C Tat mutations in cell culture
(Stellenbosch : Stellenbosch University, 2013-03)The efficiency in which HIV-1 can infect, spread and evade the attack of therapeutic agents can be attributed to a high mutation rate and frequent recombination events. These factors have collectively contributed to the ... -
B lymphocyte activation and exhaustion in chronic HIV : novel surrogate markers of generalised immune activation and selective modulation of aberrant B cell responses using vasoactive intestinal peptide (VIP)
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Introduction: Chronic HIV-1 infection is characterized by immune activation and dysregulation of immune homeostasis, which impacts on multiple immune cell types. The B-cell compartment, which plays an ... -
Barriers to HIV remission research in low- and middle-income countries
(Wiley Open Access, 2017)Introduction: HIV eradication and remission research has largely taken place in high-income countries. In low- and middleincome countries (LMIC), there may be factors that have a substantial impact on the size of the ... -
Barriers to VCT despite 13 years of community-based awareness campaigns in a peri-urban township in northern Limpopo
(Health and Medical Publishing Group (HMPG), 2010) -
Biomedical research and capacity building : bilateral collaboration between research institutes in South Africa and Cameroon
(Health & Medical Publishing Group, 2016)No abstract available -
Blood dendritic cells in chronically HIV-1 infected individuals in South Africa: Phenotype, function and immune modulation
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT :HIV-1 infection detrimentally affects CD4 T lymphocytes as well as the blood plasmacytoid (pDC) and myeloid dendritic cell (mDC) compartment. DCs act as innate sensors and as initiators and directors ... -
Candida species : species distribution and antifungal susceptibility patterns
(Health and Medical Publishing Group (HMPG), 2008)[No abstract available] -
The characterisation and expression of HIV-1 subtype C gag
(Stellenbosch : Stellenbosch University, 2002)ENGLISH ABSTRACT: The gag gene of HIV-1 encodes for one of the major structural proteins, which contains several conserved cytotoxic T cell (CTL) epitopes. Gag specific CTL responses are important in controlling viral ... -
Characterisation of new full-length HIV-1 subtype D viruses from South Africa
(2004-12)ENGLISH ABSTRACT: The first episode of HIV-1 in South Africa was documented in 1982. Homosexual transmission of the virus was the predominate mode of transmission in an epidemic of mainly HIV-1 subtype Band D infections. ... -
Characterisation of the HIV-1 subtype C Env gene and the expression of the Env protein from selected isolates in mammalian cells
(Stellenbosch : Stellenbosch University, 2003-03)ENGLISH ABSTRACT: At the end of 2002, human immunodeficiency virus (HIV) had infected 42 million people worldwide. The morbidity and mortality rate, as well as the epidemic proportions of the disease have led to ... -
Characterization of HIV-1 subtype B near full-length genome sequences identified at the start of HIV epidemic in South Africa
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY: South Africa is home to approximately 20.0% of the global Human Immunodeficiency Virus (HIV) infected population. The first reported cases of HIV-1 in the country were described in 1982 amongst the homosexual ... -
Clinical relevance of total HIV DNA in peripheral blood mononuclear cell compartments as a biomarker of HIV-associated neurocognitive
(MDPI, 2017-10-31)ENGLISH ABSTRACT: The pathogenesis of HIV-associated neurocognitive disorders is complex and multifactorial. It is hypothesized that the critical events initiating this condition occur outside the brain, particularly in ... -
Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa
(Centers for Disease Control and Prevention (CDC), 2013-10)We now report the identification of a South Africa bat derived CoV that has an even closer phylogenetic relationship with MERS-CoV. -
Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation
(Public Library of Science, 2017-07-28)Introduction: HIV-1 genotypic resistance test (GRT) interpretation systems (IS) require updates as new studies on HIV-1 drug resistance are published and as treatment guidelines evolve. Methods: An expert panel was ...
