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    Exome sequencing in a family with luminal-type breast cancer underpinned by variation in the methylation pathway 

    Van der Merwe, Nicole; Peeters, Armand V.; Pienaar, Fredrieka M.; Bezuidenhout, Juanita; Van Rensburg, Susan J.; Kotze, Maritha J. (MDPI, 2017-02-22)
    ENGLISH ABSTRACT: Panel-based next generation sequencing (NGS) is currently preferred over whole exome sequencing (WES) for diagnosis of familial breast cancer, due to interpretation challenges caused by variants of uncertain ...
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    CYP2D6 genotyping and use of antidepressants in breast cancer patients : test development for clinical application 

    Van der Merwe, Nicole; Bouwens, Christianne S. H.; Pienaar, Rika; Van der Merwe, Lize; Yako, Yandiswa Y.; Geiger, Dieter H.; Kotze, Maritha J. (Springer Verlag, 2012-05)
    Approximately 25 % of clinically important drugs and numerous environmental carcinogens are metabolised by CYP2D6. Variation in the CYP2D6 gene and concomitant use of tamoxifen (TAM) with certain antidepressants may increase ...
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    Development and application of a pathology supported pharmacogenetic test for improved clinical management of South African patients with breast cancer and associated co-morbidities 

    Van der Merwe, Nicole (Stellenbosch : Stellenbosch University, 2016-03)
    ENGLISH ABSTRACT: Three major challenges in the field of breast cancer have been identified as research priorities for this study. The first is the need to combine genetic testing of high-risk patients with familial breast ...

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    Van der Merwe, Nicole (3)
    Kotze, Maritha J. (2)Bezuidenhout, Juanita (1)Bouwens, Christianne S. H. (1)Geiger, Dieter H. (1)Peeters, Armand V. (1)Pienaar, Fredrieka M. (1)Pienaar, Rika (1)Van der Merwe, Lize (1)Van Rensburg, Susan J. (1)... View MoreSubjectPharmacogenetics (2)Antidepressants -- Treatment (1)Brca2 (1)Breast -- Cancer (1)Breast -- Cancer -- Chemotherapy (1)Breast -- Cancer -- Diagnosis (1)Breast -- Cancer -- Genetic aspects (1)Breast cancer (1)Breast cancer -- Diagnosis (1)Breast cancer -- Treament (1)... View MoreDate Issued2012 (1)2016 (1)2017 (1)Has File(s)Yes (3)
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