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MammaPrint Pre-screen Algorithm (MPA) reduces chemotherapy in patients with early-stage breast cancer

Grant, Kathleen A.; Apffelstaedt, Justus P.; Wright, Colleen A.; Myburgh, Ettienne; Pienaar, Rika; De Klerk, Manie; Kotze, Maritha J. (Health & Medical Publishing Group, 2013-07-03)

Background. Clinical and pathological parameters may overestimate the need for chemotherapy in patients with early-stage breast cancer. More accurate determination of the risk of distant recurrence is now possible with use ...

Exome sequencing in a family with luminal-type breast cancer underpinned by variation in the methylation pathway

Van der Merwe, Nicole; Peeters, Armand V.; Pienaar, Fredrieka M.; Bezuidenhout, Juanita; Van Rensburg, Susan J.; Kotze, Maritha J. (MDPI, 2017-02-22)

ENGLISH ABSTRACT: Panel-based next generation sequencing (NGS) is currently preferred over whole exome sequencing (WES) for diagnosis of familial breast cancer, due to interpretation challenges caused by variants of uncertain ...

Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer’s disease

Kotze, Maritha J.; Van Rensburg, Susan J. (SpringerLink, 2012-04)

Chronic, multi-factorial conditions caused by a complex interaction between genetic and environmental risk factors frequently share common disease mechanisms, as evidenced by an overlap between genetic risk factors ...

CYP2D6 genotyping and use of antidepressants in breast cancer patients : test development for clinical application

Van der Merwe, Nicole; Bouwens, Christianne S. H.; Pienaar, Rika; Van der Merwe, Lize; Yako, Yandiswa Y.; Geiger, Dieter H.; Kotze, Maritha J. (Springer Verlag, 2012-05)

Approximately 25 % of clinically important drugs and numerous environmental carcinogens are metabolised by CYP2D6. Variation in the CYP2D6 gene and concomitant use of tamoxifen (TAM) with certain antidepressants may increase ...

Reclassification of early stage breast cancer into treatment groups by combining the use of immunohistochemistry and microarray analysis

Grant, Kathleen A.; Myburgh, Ettienne J.; Murray, Elizabeth; Pienaar, Fredrieka M.; Kidd, Martin; Wright, Colleen A.; Kotze, Maritha J. (Academy of Science of South Africa, 2019)

ENGLISH ABSTRACT: Immunohistochemistry (IHC) is routinely used to approximate breast cancer intrinsic subtypes, which were initially discovered by microarray analysis. However, IHC assessment of oestrogen receptor (ER), ...