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Analysis of the clinical utility of gene expression profiling in relation to conventional prognostic markers in South African patients with breast carcinoma
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Breast cancer is a heterogeneous disease characterised by marked inter-individual variability in presentation, prognosis and clinical outcome. The recognition that morphological assessment has limited ...
Development and application of a pathology supported pharmacogenetic test for improved clinical management of South African patients with breast cancer and associated co-morbidities
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT: Three major challenges in the field of breast cancer have been identified as research priorities
for this study. The first is the need to combine genetic testing of high-risk patients with familial
breast ...
HPV strain prevalence and HPV-related biomarker expression in vulvar carcinoma at Tygerberg academic hospital.
(Stellenbosch : Stellenbosch University, 2019-12)
ENGLISH ABSTRACT: The incidence of vulvar carcinoma in younger women has increased, possibly due to augmented human papillomavirus (HPV) infection. Variable geographic prevalence of HPV that are associated with vulvar ...
Evaluating the role of long-term urine bio-banking on the stability of urine bio-markers in the diagnosis of pre-eclampsia
(Stellenbosch : Stellenbosch University, 2019-04)
ENGLISH ABSTRACT: The aim of the pre-eclampsia (PE) and eclampsia monitoring, prevention and treatment consortium is to develop a rapid diagnostic test for PE in pregnant women because early identification of PE would ...
Development of a novel pre-screen algorithm for cardio-metabolic risk management using a genomics database resource
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT: The timely assessment and treatment of dyslipidaemia is an important component of
cardiovascular risk screening and intervention. The apolipoprotein E (APOE) ε-2/ε-3/ε-4
polymorphism associated with ...
Automated sputum screening using the BD FocalPointTM Slide Profiler : correlation with transbronchial and transthoracic needle aspirates in a high risk population
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Background:
Sputum is a non-invasive, economic investigation whereby bronchogenic carcinoma
can be identified. Manual cytological screening is labour intensive, time-consuming
and requires a continuous ...
The investigation of bronchoalveolar lavage fluid in paediatric chronic wheezers
(Stellenbosch : Stellenbosch University., 2020-03)
ENGLISH ABSTRACT: Background: Paediatric broncho-alveolar lavage (BAL) is a minimally invasive procedure, performed during flexible bronchoscopy using isotonic saline to obtain a sample of bronchial and alveolar fluid from ...
The contribution of the placenta to the diagnosis of congenital tuberculosis
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: The aim of this pilot project was to determine whether mothers with laboratory confirmed or clinically
suspected tuberculosis (TB)
had evidence of TB in the placenta. A secondary objective was to ...
Chemotherapy naive breast cancer: a correlation study between BD Cytorich™ Red cell blocks and formalin- fixed paraffinembedded tissue blocks
(Stellenbosch : Stellenbosch University, 2019-04)
Background: The ever increasing burden of breast cancer, the most common cancer among
women, demands a diagnostic test that is rapid, reliable, informative and cost-effective;
particularly in countries with limited ...
Comparison of Xpert® Breast cancer STRAT4 assay and immunohistochemistry for the evaluation of breast cancer biomarkers in South African patients
(Stellenbosch : Stellenbosch University, 2020-12)
Background: Breast cancer is one of the most common cancers diagnosed in women and approximately 60% of breast cancer related deaths are reported in low-and middle-income countries. Breast cancer ...