Abnormal thyroid function tests in children on ethionamide treatment

Date
2011
Authors
Thee S.
Zollner E.W.
Willemse M.
Hesseling A.C.
Magdorf K.
Schaaf H.S.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Ethionamide (ETH) treatment may cause hypothyroidism. Clinical data, serum thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels were retrospectively assessed in 137 children receiving anti-tuberculosis treatment including ETH. Abnormal thyroid function tests (TFTs) were recorded in 79 (58%) children: elevated serum TSH and suppressed fT4 (n = 30), isolated elevated serum TSH (n = 20), isolated low serum fT4 (n = 28) and isolated low TSH (n = 1). The risk for biochemical hypothyroidism was higher for children on regimens including para-aminosalicylic acid and in human immunodefi ciency virus infected children. TFT abnormalities are frequent in children on ETH and are mainly due to primary hypothyroidism or euthyroid sick syndrome. © 2011 The Union.
Description
Keywords
Children, Ethionamide, Thyroid function, Tuberculosis, aminosalicylic acid, ethionamide, thyrotropin, thyroxine, adolescent, article, biochemistry, child, controlled study, drug effect, extrapulmonary tuberculosis, female, human, Human immunodeficiency virus infection, hypothyroidism, infant, lung tuberculosis, major clinical study, male, preschool child, priority journal, risk assessment, side effect, thyroid function test, thyrotropin blood level, thyroxine blood level, tuberculous lymphadenitis, tuberculous meningitis
Citation
International Journal of Tuberculosis and Lung Disease
15
9
http://www.scopus.com/inward/record.url?eid=2-s2.0-80051677011&partnerID=40&md5=a953a22a34c04b77b76745e7004842bc
URI
http://hdl.handle.net/10019.1/16655
Collections
Stellenbosch University - Scopus Publications