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Cyclopia extracts act as ERα antagonists and ERβ agonists, in vitro and in vivo

Visser, Koch; Mortimer, Morne; Louw, Ann (Public Library of Science (PLOS), 2013-11)

Hormone replacement therapy associated risks, and the concomitant reluctance of usage, has instigated the search for new generations of estrogen analogues that would maintain estrogen benefits without associated ...

Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ

Verhoog, Nicolette; Allie-Reid, Fatima; Vanden Berghe, Wim; Smith, Carine; Haegeman, Guy; Hapgood, Janet; Louw, Ann (2014-10)

Corticosteroid-binding globulin (CBG), a negative acute phase protein produced primarily in the liver, is responsible for the transport of glucocorticoids (GCs). It also modulates the bioavailability of GCs, as only free ...

Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution

Robertson, Steven; Hapgood, Janet P.; Louw, Ann (Elsevier, 2013-02)

Glucocorticoid receptor (GR) concentrations and the ability of the GR to dimerize are factors which influence sensitivity to glucocorticoids. Upon glucocorticoid binding, the GR is actively transported into the nucleus, ...

Impact of glucocorticoid receptor density on ligand- independent dimerization, cooperative ligand-binding and basal priming of transactivation : a cell culture model

Robertson, Steven; Rohwer, Johann M.; Hapgood, Janet P; Louw, Ann (Public Library of Science -- PLoS, 2013-05)

Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiological and pharmacological effectors. However, the effects and implications of differences in GR concentration have not ...

Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats

Louw, Ann; Swart, P. (The Endocrine Society, 1999-05)

Salsola tuberculatiformis Botschantzev causes prolonged gestation in sheep and contraception in rats. An active fraction isolated from the shrub, containing a highly labile hydoxyphenyl aziridine or precursor, and a ...

Screening of four Cyclopia (honeybush) species for putative phyto-oestrogenic activity by oestrogen receptor binding assays

Verhoog, N. J. D.; Joubert, E.; Louw, Ann (AOSIS OpenJournals, 2007)

Phyto-oestrogens mediate an oestrogenic effect through binding to the oestrogen receptor (ER) subtypes, ERα and ERβ. Four commercially available Cyclopia (honeybush) species - C. intermedia, C. subternata, C. genistoides ...

Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A

Robertson, Steven; Allie-Reid, Fatima; Vanden Berghe, Wim; Visser, Koch; Binder, Anke; Africander, Donita; Vismer, Michael; De Bosscher, Karolien; Hapgood, Janet; Haegeman, Guy; Louw, Ann (HighWire Press, 2010-03)

Compound A (CpdA), a dissociated glucocorticoid receptor modulator, decreases corticosteroid-binding globulin (CBG), adrenocorticotropic hormone (ACTH), and luteneinizing hormone levels in rats. Whether this is due to ...

Interplay of the inflammatory and stress systems in a hepatic cell line : interactions between glucocorticoid receptor agonists and interleukin-6

Visser, Koch; Smith, Carine; Louw, Ann (HighWire Press, 2010-11)

The liver plays an important role in inflammation and stress by producing the acute phase proteins (APPs) required for resolution of inflammation as well as by delivering systemic glucose, through gluconeogenesis, required ...

Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6

Smith, C.; Wilson, N. W.; Louw, Ann; Myburgh, K. H. (American Physiological Society, 2006-12)

ACUTE PSYCHOLOGICAL STRESS is known to activate the hypothalamic- pituitary-adrenal (HPA) axis, resulting in transiently increased release of inflammatory cytokines (28) and glucocorticoids (45). In contrast, multiple ...

South African herbal teas : Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides - a review

Joubert, E.; Gelderblom, W. C. A.; Louw, Ann; De Beer, D. (Elsevier, 2008-10)

Rooibos (Aspalathus linearis (Brum.f) Dahlg.) and honeybush (Cyclopia Vent. species) are popular indigenous South African herbal teas enjoyed for their taste and aroma. Traditional medicinal uses of rooibos in South ...