Now showing items 1-10 of 19
The variability of autophagy and cell death susceptibility : unanswered questions
(Landes Bioscience, 2013-09)
Impaired autophagic machinery is implicated in a number of diseases such as heart disease, neurodegeneration and cancer. A common denominator in these pathologies is a dysregulation of autophagy that has been linked to a ...
The secret of dying well : the many faces of cell death and its relevance for treating diseases of our time
(Stellenbosch : Stellenbosch University, 2014-03)
Anna-Mart Engelbrecht is currently professor in the Department of Physiological Sciences at Stellenbosch University. She was born in Pretoria, grew up in the Western Cape and matriculated from DF Malan High School in ...
Enhanced therapeutic efficacy in cancer patients by short-term fasting : the autophagy connection
(Frontiers Media, 2016)
Preclinical studies suggest that fasting prior to chemotherapy may be an effective strategy to protect patients against the adverse effects of chemo-toxicity. Fasting may also sensitize cancer cells to chemotherapy. It is ...
Bcl‑2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose‑dependent toxicity and resistance
(BioMed Central, 2015-10)
Background: Cisplatin is the main chemotherapeutic drug for the treatment of cervical cancers, however resistance to cisplatin is increasingly common and therefore has limited the efficacy and use of this drug in the ...
Commentary on : "A common origin for immunity and digestion"
(Frontiers Media, 2015-05)
The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart : the involvement of the PI3-Kinase signaling pathway
(BioMed Central, 2009-05)
We have previously shown that dietary red palm oil (RPO) supplementation improves functional recovery in hearts subjected to ischaemia/reperfusion-induced injury. Unfortunately, the cellular and molecular mechanisms ...
Chemoresistance : intricate interplay between breast tumor cells and adipocytes in the tumor microenvironment
(Frontiers Media, 2018-12-11)
Excess adipose tissue is a hallmark of an overweight and/or obese state as well as a primary risk factor for breast cancer development and progression. In an overweight/obese state adipose tissue becomes dysfunctional due ...
Decreased efficacy of doxorubicin corresponds with modifications in lipid metabolism markers and fatty acid profiles in breast tumors from obese vs. lean mice
(Frontiers Media, 2018-03-17)
Breast cancer cells modulate lipid and fatty acid metabolism to sustain proliferation. The role of adipocytes in cancer treatment efficacy remains, however, to be fully elucidated. We investigated whether diet-induced ...
Sickness-associated anorexia : mother nature’s idea of immunonutrition?
(Hindawi Publishing Corporation, 2016)
During an infection, expansion of immune cells, assembly of antibodies, and the induction of a febrile response collectively place continual metabolic strain on the host. These considerations also provide a rationale for ...
Was the evolutionary road towards adaptive immunity paved with endothelium?
(BioMed Central, 2015)
Background: The characterization of a completely novel adaptive immune system (AIS) in jawless vertebrates (hagfish and lampreys) presents an excellent opportunity for exploring similarities and differences in design principles. ...