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Now showing items 1-20 of 36
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Variance estimation for Markov processes
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: We study the asymptotic variance of additive functionals of Markov processes, used in statistics and stochastic modelling as estimators of model parameters. The observations generated by these processes ... -
Towards the development of a MIR NOPA for time-domain ptychography
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: This thesis discusses a noncollinear optical parametric amplifier as a source of ultrafast mid-infrared light for spectroscopic experiments and aims to provide a consistent method for the generation ... -
Towards automated detection of dicentric chromosomes in metaphase images
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: The aim of the proposed research is to investigate methods to identify objects of interest and classify dicentric and normal chromosomes in metaphase images using suitable digital image processing ... -
Towards a nuanced view of diagnostic test properties: an application to transfusion transmitted risk estimation
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Laboratory screening (rather than pathogen inactivation) is likely to remain, for the foreseeable future, the primary means of ensuring the safety of blood products from transfusion transmissible viruses ... -
Thermoresponsive hydrogels from poly(ethylene glycol)-based graft poly(dimethyl siloxane) amphiphilic copolymers with tunable lower critical solution temperatures
(Stellenbosch : Stellenbosch University, 2021, 2021-03)ENGLISH ABSTRACT: This study aimed to investigate poly(oligo(ethylene glycol) methyl ether methacrylate)-graft-poly(dimethyl siloxane) copolymer materials as potential precursor materials to produce polymer nanofibre ... -
Ternary hydrogel blends of water-soluble polymers: A fundamental study
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Poly(vinyl alcohol) (PVA) is a water-soluble polymer. The use of PVA in the preparation of hydrogels has been well reported. However, PVA is not inherently antimicrobial, thus if this polymer is to be ... -
Synthesis of 2,2-dipyridylamine organometallic complexes for antiplasmodial application
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Six iridium, rhodium and ruthenium half-sandwich organometallic complexes (C1-C6) of the ligand 2,2- dipyridilamine with either a chlorido and iodido ancillary ligand were synthesized using a reported method ... -
Structure-property relationships in PVC-lubricant compounds
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: This thesis was constructed with the aim of developing and improving current methods for tracking lubricants during the single screw extrusion of unplasticized polyvinyl chloride (uPVC). First a set of ... -
Spill your guts: the invasive amphibian gut microbiome
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Invasive vertebrate species threaten global biodiversity, and significantly impact economic, agricultural and ecosystem services. Alarmingly, the number of introductions of species into non-native areas ... -
Single-beam coherent anti-Stokes Raman scattering combining polarization shaping with spectral focusing
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Single-beam coherent anti-Stokes Raman scattering (SB-CARS is a compact approach to CARS which employs a single broadband laser source to probe molecular vibrations. A variety of light sources can be used, ... -
Schizophrenia: Effect of Fluanxol® treatment on redox status
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Oxidative stress has been implicated in the pathology of schizophrenia, with impaired antioxidant mechanisms observed in these patients. The modulatory role of oxidative stress on the activity of NMDA ... -
A review of the measurement problem in quantum mechanics
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Quantum Mechanics has been a massively successful theory, but for all its success it is at odds with our experiences at the macroscopic or classical level. This tension between the quantum and classical ... -
Radon levels in South African homes - design elements for a national survey and initial results from directed sampling
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Radon (222Rn) is an inert, colourless, odourless radioactive gas that is generated by the alpha decay of radium (226Ra), a radionuclide in the uranium (238U) decay series. Radon (222Rn) is the primary ... -
Multi-guide particle swarm optimization for many-objective optimization problems
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: The scalability of the multi-guide particle swarm optimization (MGPSO) algorithm, with respect to the number of objectives for a problem, is investigated. Two MGPSO algorithm adaptations are proposed; ... -
Mathematical modelling of glycolysis in differentiated mouse adipocytes 3T3-L1
(Stellenbosch : Stellenbosch UniversityStellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Diabetes mellitus is a metabolic disease characterised by high blood sugar levels, primarily caused by insulin resistance and the resulting inability of the body to process glucose. Any tissue or cell ... -
Mathematical modelling of glycolysis in cancer cell lines
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Most cancer cells exhibit an increase in glucose uptake and lactate produc- tion, a phenomenon known as the "Warburg effect" or aerobic glycolysis, and considered to be a hallmark of cancer ... -
Light sheet fluorescence microscopy
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Light sheet fluorescence microscopy is a powerful tool within the in field of microscopy. The inherent advantages over other fluorescence microscopy techniques include high sectioning capabilities, ... -
Investigating the solid-state dynamics of 1D coordination polymers
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: The aims of this study were twofold: (i) to produce a series of 1D materials exhibiting novel solid-state packing, and (ii), to study these materials with a view to gaining insight into their structure-property ... -
Investigating regional recharge dynamics through the use of tritium and radiocarbon isotopes to assess the hydrological resilience of groundwater in southern Africa
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Water resources are integral in the global pursuit of equitable growth and sustainability. Although groundwater is the most abundant freshwater resource accessible to humans and the environment, it is ... -
Identification of potential biomarkers of cardiotoxicity induced by doxorubicin therapy in a tumour bearing model by targeting specific micro-RNAs
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Introduction: Anthracycline-induced cardiotoxicity, a major side effect of chemotherapeutic drugs such as doxorubicin (DOX), has been a priority within the field of cardio-oncology for a number of decades. ...
