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Validation of equations to estimate glomerular filtration rate in South Africans of mixed ancestry
(Health & Medical Publishing Group, 2020-02-26)
Background. The Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations are two commonly used formulae to estimate glomerular filtration rate (GFR) in adults. ...
How useful are clinical details in blunt trauma referrals for computed tomography of the abdomen?
(AOSIS, 2020-04-22)
Background: The relevance of clinical data included in blunt trauma referrals for abdominal computed tomography (CT) is not known.
Objectives: To analyse the clinical details provided on free-text request forms for abdominal ...
Diffusion tensor imaging point to ongoing functional impairment in HIV-infected children at age 5, undetectable using standard neurodevelopmental assessments
(BMC (part of Springer Nature), 2020-05-19)
Background: Perinatal HIV infection negatively impacts cognitive functioning of children, main domains affected are working memory, processing speed and executive function. Early ART, even when interrupted, improves ...
Validation of a cost-effective alternative for a radiochromatography method to be used in a developing country
(SpringerOpen (part of Springer Nature), 2020-04-10)
Introduction: The radiochemical purity (RCP) of technetium-99m labelled
radiopharmaceuticals (RP) is important to ensure optimal scintigraphic image quality.
In low-income settings, it may not be possible to use compendial ...
Results from extended lymphadenectomies with [111In]PSMA-617 for intraoperative detection of PSMA-PET/CT-positive nodal metastatic prostate cancer
(SpringerOpen (part of Springer Nature), 2020-03-06)
Purpose: Identification of suspicious PSMA-PET/CT-positive lymph node (LN) metastases (LNM) from prostate
cancer (PCa) during lymphadenectomy (LA) is challenging. We evaluated an 111In-labelled PSMA ligand (DKFZ-617,
referred ...
Optimization of production methods for gallium-68 PET radiopharmaceuticals in a hospital radiopharmacy
(Stellenbosch : Stellenbosch University, 2020-12)
ENGLISH SUMMARY : Production of radiopharmaceuticals intended for human use and research purposes is generally performed in well-equipped commercial or research facilities that usually have access to advanced equipment for ...
Influence of acquisition time and smoothing parameters on Ga-68 wholebody PET/CT image quality
(Stellenbosch : Stellenbosch University, 2020-12)
ENGLISH SUMMARY : PET/CT image optimization has been extensively investigated for 18F–FDG PET
imaging. Although 68Ga–tracers are already widely used in PET, optimized imaging and reconstruction are still missing. The aim ...
Implementation of guidelines on hospital radiopharmacy in low-income settings
(Stellenbosch : Stellenbosch University, 2020-12)
ENGLISH SUMMARY : Although radiopharmacy is more than 50 years old, it is still in a stage of rapid development. This dissertation focuses on quality issues in radiopharmacies in developing countries. Guidelines for ...
The use of HEPES-buffer in the production of gallium-68 radiopharmaceuticals – time to reconsider strict pharmacopoeial limits?
(SpringerOpen (part of Springer Nature), 2021-04-01)
ENGLISH ABSTRACT: HEPES (4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) is a buffer that is used in
the radiolabelling of gallium-68 compounds. The beneficial effects of HEPES on
molar activity in bioconjugates ...
Dual energy window imaging for optimisation of P/V ratios in VP SPECT
(SpringerOpen, 2021)
Purpose: Ventilation–perfusion single-photon emission computed tomography (VP SPECT) plays an important role in pulmonary embolism diagnosis. Rapid results may
be obtained using same-day ventilation followed by perfusion ...