No significant differences in peritoneal fluid handling in children using pH-neutral or acidic solutions
Date
2006
Authors
Nourse P.
van de Kar N.C.A.J.
Willems H.L.
Schroder C.H.
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Abstract
◆ Objectives: Differences in peritoneal fluid handling in the acute setting can be expected if children are converted to pH-neutral dialysis solutions because conventional acidic solutions exert toxic effects on peritoneal mesothelial cells and microcirculation. Peritoneal fluid kinetics was therefore investigated with both types of solutions in a group of children. ◆ Design: Peritoneal equilibration tests (PETs) were performed in 12 patients [mean age 70 months, mean time on peritoneal dialysis (PD) 18 months] using a pH-neutral PD fluid (Physioneal 3.86%; Baxter Ltd, Castlebar, Ireland) and dextran 70 as a volume marker. The results of these PETs were compared to those of a historic group of 12 children (mean age 75 months, mean time on PD 17 months). ◆ Setting: Pediatric dialysis unit in a tertiary institute. ◆ Patients: Stable pediatric PD patients. ◆ Main Outcome Measures: Transcapillary ultrafiltration (TCUF) and marker clearance, dialysate-to-plasma (D/P) ratios for urea and creatinine, and Dt/D0 ratio for glucose. ◆ Results: TCUF and lymphatic absorption were not different between the two groups. There was also no significant difference in small solute clearance measured by D/P ratio for urea and creatinine and Dt/D0 ratio for glucose. ◆ Conclusion: Peritoneal fluid kinetics is not significantly altered if pH-neutral dialysis solutions are applied compared to acidic solutions. An altered TCUF, as is hypothetically possible using an acidic solution, was not established. Copyright © 2006 International Society for Peritoneal Dialysis.
Description
Keywords
antihypertensive agent, creatinine, dextran, dianeal, glucose, peritoneal dialysis fluid, physioneal, unclassified drug, urea, acidity, article, clearance, clinical article, controlled study, dialysate, glucose transport, health care facility, human, hypertension, kidney failure, pediatric hospital, peritoneal dialysis, peritoneal fluid, peritonitis, pH, preschool child, priority journal, solute, tertiary health care, transport kinetics, treatment duration, ultrafiltration, Child, Child, Preschool, Creatinine, Dialysis Solutions, Follow-Up Studies, Glucose, Humans, Hydrogen-Ion Concentration, Infant, Kidney Failure, Chronic, Peritoneal Dialysis, Peritoneum, Urea
Citation
Peritoneal Dialysis International
26
5
26
5