The effect of medial forebrain bundle lesion on thyrotropin secretion in the rat
Date
1991
Authors
Jaffer A.
Daniels W.M.U.
Russell V.A.
Taljaard J.J.F.
Journal Title
Journal ISSN
Volume Title
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Abstract
The medial forebrain bundle (MFB) was partially lesioned with 6-hydroxydopamine (6-OHDA) in order to investigate the effect of deficient central noradrenergic regulation on thyrotropin (TSH) secretion in the rat. 6-OHDA injection into the MFB significantly reduced the noradrenaline (NA), dopamine (DA) and serotonin (5-HT) content of the whole hypothalamus. NA and 5-HT concentrations were also significantly decreased in the paraventricular nucleus (PVN). The MFB lesion did not affect the clonidine (250 μg/kg, i.p.) induced stimulation of TSH release or the isoproterenol (1 mg/kg i.p.) induced decrease in TSH levels. Thyrotropin releasing hormone (TRH, 5 μg/kg i.v.) caused a similar significant stimulation of TSH secretion in lesioned and non-lesioned rats. The present results do not support the hypothesis that the blunted TSH response to TRH observed in depressed patients results from a deficiency in noradrenergic neurotransmission.
Description
Keywords
clonidine, isoprenaline, protirelin, animal experiment, animal tissue, article, catecholamine brain level, controlled study, drug sensitivity, male, medial forebrain bundle, nonhuman, noradrenergic system, priority journal, rat, thyroid hormone blood level, Animal, Clonidine, Dopamine, Isoproterenol, Male, Norepinephrine, Oxidopamine, Prosencephalon, Protirelin, Rats, Rats, Inbred Strains, Serotonin, Support, Non-U.S. Gov't, Thyrotropin, Animalia
Citation
Neurochemical Research
16
5
16
5