Diffusion MRI findings in Wilson's disease
Date
2003
Authors
Sener R.N.
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Abstract
Six patients having Wilson's disease were studied with diffusion MRI in order to characterize cerebral lesions. Diffusion MRI was obtained using the spin-echo, echo-planar sequence with a gradient strength of 30mT/m. The trace protocol was used in the axial imaging plane. Heavily diffusion-weighted (b=1000s/mm2) images, and the ADC (apparent diffusion coefficient) values from automatically generated ADC maps were studied. The ADC values of the normal brain parenchyma were available in 17 age-matched cases for comparison (ADC values, 0.85±0.11×10-3mm2/s). In Wilson's disease two distinct diffusion MRI patterns were observed by quantitative evaluations of the ADC maps; cytotoxic edema-like (ADC values, 0.52±0.03×10-3mm2/s), and vasogenic edema-like (ADC values, 1.42±0.17×10-3mm2/s) patterns. Diffusion imaging appears to be a promising sequence to evaluate the changes in the brain tissue in Wilson's disease at least by revealing two different patterns. © 2002 Elsevier Science Ltd. All rights reserved.
Description
Keywords
Brain, Diffusion, Magnetic resonance imaging, Tissue, Cerebral lesions, Medical imaging, adolescent, article, brain edema, brain tissue, child, clinical article, controlled study, cytotoxicity, diagnostic imaging, diffusion, female, human, image analysis, male, nuclear magnetic resonance imaging, priority journal, quantitative analysis, Wilson disease, Adolescent, Brain, Case-Control Studies, Child, Diffusion Magnetic Resonance Imaging, Female, Hepatolenticular Degeneration, Humans, Male
Citation
Computerized Medical Imaging and Graphics
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