Diffusion MRI findings in Wilson's disease

Sener R.N. (2003)


Six patients having Wilson's disease were studied with diffusion MRI in order to characterize cerebral lesions. Diffusion MRI was obtained using the spin-echo, echo-planar sequence with a gradient strength of 30mT/m. The trace protocol was used in the axial imaging plane. Heavily diffusion-weighted (b=1000s/mm2) images, and the ADC (apparent diffusion coefficient) values from automatically generated ADC maps were studied. The ADC values of the normal brain parenchyma were available in 17 age-matched cases for comparison (ADC values, 0.85±0.11×10-3mm2/s). In Wilson's disease two distinct diffusion MRI patterns were observed by quantitative evaluations of the ADC maps; cytotoxic edema-like (ADC values, 0.52±0.03×10-3mm2/s), and vasogenic edema-like (ADC values, 1.42±0.17×10-3mm2/s) patterns. Diffusion imaging appears to be a promising sequence to evaluate the changes in the brain tissue in Wilson's disease at least by revealing two different patterns. © 2002 Elsevier Science Ltd. All rights reserved.

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