Effects of adrenaline, administered early or later after ischaemia, and reperfusion on the isolated rat heart
Date
1998
Authors
De Glanville N.
Lochner A.
Coetzee A.
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Abstract
Objective. To evaluate the effect of adrenaline on cardiac function when given early or later in the reperfusion period. Design. Prospective study. Setting. University laboratory. Participants. Wistar rats. Interventions. Isolated rat hearts were subjected to 45 minutes of normothermic ischaemic arrest. During reperfusion, adrenaline was administered early (2 minutes) or later (12 minutes) after termination of ischaemic arrest in addition to a short (5 minutes) or longer (10 minutes) recovery period before function was resumed. Measurements and results. Aortic and coronary flow, peak systolic pressure and heart rate were determined before arrest, 10 and 15 minutes after termination of ischaemic arrest. Adenosine triphosphate and creatine phosphate levels were also determined after cardioplegic arrest and reperfusion. Results indicate that early administration of adrenaline was not detrimental but that a longer recovery period after arrest resulted in significantly better cardiac function. Conclusion. After ischaemic arrest of the isolated rat heart a longer recovery period resulted in better cardiac function than a shorter period of recovery.
Description
Keywords
adrenalin, animal experiment, article, coronary artery blood flow, drug effect, heart function, heart muscle ischemia, heart muscle reperfusion, nonhuman, rat, systolic blood pressure, Animals, Drug Administration Schedule, Electrophysiology, Epinephrine, Heart Arrest, Induced, Hemodynamic Processes, Humans, Myocardial Ischemia, Myocardial Reperfusion Injury, Phosphates, Prospective Studies, Rats, Rats, Wistar
Citation
Cardiovascular Journal of South Africa
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