Are neuroendocrine cells of practical value as an independent prognostic parameter in prostate cancer?
Date
1995
Authors
Allen F.J.
Van Velden D.J.J.
Heyns C.F.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective - To assess whether the presence of neuroendocrine (NE) cells is of value as an independent indicator of poor prognosis in patients with prostate carcinoma. Patients and methods - A series of 160 consecutive patients with prostate carcinoma was studied retrospectively. In 120 there was sufficient tissue for review and to perform immunoperoxidase stains for neuron specific enolase (NSE) and chromogranin A (CGA). All patients had a potential follow-up of at least 5 years. Results - Five-year survival was poorer for patients with a high tumour grade and stage at presentation compared to those with a lower grade and stage. NE cells were more common in higher grade and stage disease, but S-year survival did not differ significantly between patients with NE cell positive and negative tumours. Conclusion - NE cells are of no practical value as an independent prognostic indicator in patients with prostatic adenocarcinoma.
Description
Keywords
chromogranin, neuron specific enolase, article, cancer grading, cancer staging, follow up, human, immunoperoxidase staining, major clinical study, neuroendocrine disease, priority journal, prognosis, prostate cancer, retrospective study, survival, Adenocarcinoma, Aged, Aged, 80 and over, Follow-Up Studies, Human, Male, Middle Age, Neurosecretory Systems, Prognosis, Prostatic Neoplasms, Retrospective Studies, Survival Analysis
Citation
British Journal of Urology
75
6
75
6