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Rat brain hypothalamic and hippocampal monoamine and hippocampal β-adrenergic receptor changes during pregnancy

Rat brain hypothalamic and hippocampal monoamine and hippocampal β-adrenergic receptor changes during pregnancy

dc.contributor.authorGlaser J.
dc.contributor.authorRussell V.A.
dc.contributor.authorTaljaard J.J.F.
dc.contributor.authorGlaser J.
dc.contributor.authorRussell V.A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:15:44Z
dc.date.accessioned2011-05-15T16:15:44Z
dc.date.available2011-05-15T16:15:44Z
dc.date.available2011-05-15T16:15:44Z
dc.date.issued1992
dc.date.issued1992
dc.identifier.citationBrain Research
dc.identifier.citation577
dc.identifier.citation2
dc.identifier.citationBrain Research
dc.identifier.citation577
dc.identifier.citation2
dc.identifier.issn00068993
dc.identifier.issn00068993
dc.identifier.other10.1016/0006-8993(92)90286-I
dc.identifier.other10.1016/0006-8993(92)90286-I
dc.identifier.urihttp://hdl.handle.net/10019.1/13464
dc.identifier.urihttp://hdl.handle.net/10019.1/13464
dc.description.abstractThe concentration of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites was measured in hypothalamic and hippocampal brain tissue obtained from non-pregnant, 15- or 20-day pregnant and 4-day postpartum rats. At 20 days of pregnancy, hypothalamic NA and DA concentrations were significantly decreased and their turnover increased relative to postpartum and estrous values, respectively. Hippocampal 3-methoxy-4-hydroxy-phenylglycol (MHPG) levels were significantly decreased at 15 days of pregnancy and 4 days postpartum compared to estrous and 20-day pregnant levels and the MHPG/NA ratio was significantly reduced at 4 days postpartum relative to the estrous value. Hippocampal 5-HT and 5-hydroxyindole-3-acetic acid (5-H1AA) levels were significantly decreased at 15 days of pregnancy while 5-HIAA levels and the 5-HIAA/5-HT ratio were significantly decreased at 20 days of pregnancy. Hippocampal β-adrenergic receptor density was significantly lower at 4 days postpartum than at 15 days of pregnancy. A positive correlation was observed between plasma progesterone and hippocampal β-adrenoceptor K(d) values, suggesting a possible causal relationship between these two variables. The monoamine and β-adrenoceptor changes which occur during pregnancy may be an important contributing factor in determining the mood changes which occur during pregnancy and postpartum.
dc.description.abstractThe concentration of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites was measured in hypothalamic and hippocampal brain tissue obtained from non-pregnant, 15- or 20-day pregnant and 4-day postpartum rats. At 20 days of pregnancy, hypothalamic NA and DA concentrations were significantly decreased and their turnover increased relative to postpartum and estrous values, respectively. Hippocampal 3-methoxy-4-hydroxy-phenylglycol (MHPG) levels were significantly decreased at 15 days of pregnancy and 4 days postpartum compared to estrous and 20-day pregnant levels and the MHPG/NA ratio was significantly reduced at 4 days postpartum relative to the estrous value. Hippocampal 5-HT and 5-hydroxyindole-3-acetic acid (5-H1AA) levels were significantly decreased at 15 days of pregnancy while 5-HIAA levels and the 5-HIAA/5-HT ratio were significantly decreased at 20 days of pregnancy. Hippocampal β-adrenergic receptor density was significantly lower at 4 days postpartum than at 15 days of pregnancy. A positive correlation was observed between plasma progesterone and hippocampal β-adrenoceptor K(d) values, suggesting a possible causal relationship between these two variables. The monoamine and β-adrenoceptor changes which occur during pregnancy may be an important contributing factor in determining the mood changes which occur during pregnancy and postpartum.
dc.subjectadrenergic receptor; cyanoiodopindolol; dopamine; noradrenalin; serotonin; animal experiment; animal tissue; article; controlled study; female; hippocampus; hypothalamus; nonhuman; pregnancy; priority journal; puerperium; rat; Animal; Biogenic Monoamines; Female; Hippocampus; Hypothalamus; Mood Disorders; Pregnancy; Progesterone; Puerperal Disorders; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Support, Non-U.S. Gov't
dc.subjectadrenergic receptor
dc.subjectcyanoiodopindolol
dc.subjectdopamine
dc.subjectnoradrenalin
dc.subjectserotonin
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthippocampus
dc.subjecthypothalamus
dc.subjectnonhuman
dc.subjectpregnancy
dc.subjectpriority journal
dc.subjectpuerperium
dc.subjectrat
dc.subjectAnimal
dc.subjectBiogenic Monoamines
dc.subjectFemale
dc.subjectHippocampus
dc.subjectHypothalamus
dc.subjectMood Disorders
dc.subjectPregnancy
dc.subjectProgesterone
dc.subjectPuerperal Disorders
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectReceptors, Adrenergic, beta
dc.subjectSupport, Non-U.S. Gov't
dc.titleRat brain hypothalamic and hippocampal monoamine and hippocampal β-adrenergic receptor changes during pregnancy
dc.titleRat brain hypothalamic and hippocampal monoamine and hippocampal β-adrenergic receptor changes during pregnancy
dc.typeArticle
dc.typeArticle
dc.description.versionArticle
dc.description.versionArticle


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