Hypoosmotic swelling test in the prediction of male fertility
Date
1989
Authors
Coetzee K.
Kruger T.F.
Menkveld R.
Lombard C.J.
Swanson R.J.
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Journal ISSN
Volume Title
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Abstract
The hypoosmotic swelling test (HOS) is a simple test to measure the functional competence of human sperm membranes. The question is, does a relationship exist between this competence and the fertilization potential of human spermatozoa? In this study the strongest correlation (r = 0.76) was obtained between sperm swelling and sperm viability (supravital staining). Only a moderate correlation (r = 0.50) was obtained with normal sperm morphology; weaker correlations were also obtained with the sperm penetration assay (r = 0.42) and human IVF (r = 0.24). The results, therefore, indicate that the HOS test has a limited predictive value. Notwithstanding this low concordance between sperm swelling and fertilizing potential, a <50% HOS test threshold was seen to be a definite indicator of a male factor.
Description
Keywords
cell culture, cell volume, controlled study, fertilization in vitro, human cell, infertility, male, methodology, normal human, osmoregulation, priority journal, spermatozoon, Cell Survival, Female, Fertility, Human, Male, Osmolar Concentration, Sperm-Ovum Interactions, Spermatozoa
Citation
Archives of Andrology
23
2
23
2